Fat, when used for reconstruction, is usually mixed with PRP to improve survival. The following two articles show that when fat is used for reconstruction post-breast cancer, there is a trend toward fewer recurrences.
Eichler, C., C. Baucks, J. Üner, C. Pahmeyer, D. Ratiu, B. Gruettner, W. Malter, and M. Warm. “Platelet-Rich Plasma (PRP) in Breast Cancer Patients: An Application Analysis of 163 Sentinel Lymph Node Biopsies.” Edited by Xin-yuan Guan.
BioMed Research International 2020 (October 22, 2020): 1–7.
https://doi.org/10.1155/2020/3432987.
Kaoutzanis, Christodoulos, Minqiang Xin, Tiffany N.S. Ballard, Kathleen B. Welch, Adeyiza O. Momoh, Jeffrey H. Kozlow, David L. Brown, Paul S. Cederna, and Edwin G. Wilkins. “Autologous Fat Grafting After Breast Reconstruction in Postmastectomy Patients: Complications, Biopsy Rates, and Locoregional Cancer Recurrence Rates.”
Annals of Plastic Surgery 76, no. 3 (March 2016): 270–75.
https://doi.org/10.1097/SAP.0000000000000561.
Kronowitz, Steven J., Cosman Camilo Mandujano, Jun Liu, Henry M. Kuerer, Benjamin Smith, Patrick Garvey, Reshma Jagsi, Limin Hsu, Summer Hanson, and Vicente Valero. “Lipofilling of the Breast Does Not Increase the Risk of Recurrence of Breast Cancer: A Matched Controlled Study.” Plastic and Reconstructive Surgery 137, no. 2 (February 2016): 385–93. https://doi.org/10.1097/01.prs.0000475741.32563.50.
Eichler, Christian, Jens Üner, Fabinshy Thangarajah, Julia Radosa, Max Zinser, Lotta Ada Fischer, Julian Puppe, Matthias Warm, Wolfram Malter, and Caroline Lenz. “Platelet-Rich Plasma (PRP) in Oncological Patients: Long-Term Oncological Outcome Analysis of the Treatment of Subcutaneous Venous Access Device Scars in 89 Breast Cancer Patients.”
Archives of Gynecology and Obstetrics, April 4, 2022.
https://doi.org/10.1007/s00404-022-06416-4.
Since PRP has strong antibacterial qualities, and since those with breast cancer present a more inflammatory microbiota, the anti-bacterial effects may be partly responsible for the trend toward fewer recurrences.
Urbaniak, Camilla, Gregory B. Gloor, Muriel Brackstone, Leslie Scott, Mark Tangney, and Gregor Reid. “The Microbiota of Breast Tissue and Its Association with Breast Cancer.” Edited by H. Goodrich-Blair. Applied and Environmental Microbiology 82, no. 16 (August 15, 2016): 5039–48. https://doi.org/10.1128/AEM.01235-16.
Saleh, Doaa M., and Rania Abdelghani. “Clinical Evaluation of Autologous Platelet Rich Plasma Injection in Postmenopausal Vulvovaginal Atrophy: A Pilot Study.”
Journal of Cosmetic Dermatology n/a, no. n/a. Accessed March 9, 2022.
https://doi.org/10.1111/jocd.14873.
Samaie Nouroozi, Atefeh, Ashraf Alyasin, Ashraf Malek Mohammadi, Nili Mehrdad, Seyed Asadollah Mossavi, Mohammad Vaezi, atoosa Gharib, Ardeshir Ghavamzadeh, and Saeed Mohammadi. “Autologous Platelet-Released Growth Factor and Sexual Dysfunction Amendment: A Pilot Clinical Trial of Successful Improvement Sexual Dysfunction after Pelvic Irradiation.”
Asian Pacific Journal of Cancer Prevention 20, no. 3 (March 1, 2019): 817–23.
https://doi.org/10.31557/APJCP.2019.20.3.817.
Zheng, Zhifang, Junfeiyang Yin, Biao Cheng, and Wenhua Huang. “Materials Selection for the Injection into Vaginal Wall for Treatment of Vaginal Atrophy.” Aesthetic Plastic Surgery 45, no. 3 (June 1, 2021): 1231–41. https://doi.org/10.1007/s00266-020-02054-w.
Aggour, Reham L., and Lina Gamil. “Antimicrobial Effects of Platelet-Rich Plasma against Selected Oral and Periodontal Pathogens.”
Polish Journal of Microbiology 66, no. 1 (April 3, 2017): 31–37.
https://doi.org/10.5604/17331331.1235227.
Cieslik-Bielecka, A., D. M. Dohan Ehrenfest, A. Lubkowska, and T. Bielecki. “Microbicidal Properties of Leukocyte- and Platelet-Rich Plasma/Fibrin (L-PRP/L-PRF): New Perspectives.” Journal of Biological Regulators and Homeostatic Agents 26, no. 2 Suppl 1 (2012).
Sethi, Dalip, Kimberly E. Martin, Sangeeta Shrotriya, and Bethany L. Brown. “Systematic Literature Review Evaluating Evidence and Mechanisms of Action for Platelet-Rich Plasma as an Antibacterial Agent.”
Journal of Cardiothoracic Surgery 16, no. 1 (September 28, 2021): 277.
https://doi.org/10.1186/s13019-021-01652-2.
Zhang, Wenhai, Yue Guo, Mitchell Kuss, Wen Shi, Amy L. Aldrich, Jason Untrauer, Tammy Kielian, and Bin Duan. “Platelet-Rich Plasma for the Treatment of Tissue Infection: Preparation and Clinical Evaluation.”
Tissue Engineering. Part B, Reviews 25, no. 3 (June 1, 2019): 225–36.
https://doi.org/10.1089/ten.teb.2018.0309