Tag: research

  • The O-Shot® after Breast Cancer–a Sampling of Research

    Fat, when used for reconstruction, is usually mixed with PRP to improve survival. The following two articles show that when fat is used for reconstruction post-breast cancer, there is a trend toward fewer recurrences.

    Eichler, C., C. Baucks, J. Üner, C. Pahmeyer, D. Ratiu, B. Gruettner, W. Malter, and M. Warm. “Platelet-Rich Plasma (PRP) in Breast Cancer Patients: An Application Analysis of 163 Sentinel Lymph Node Biopsies.” Edited by Xin-yuan Guan. BioMed Research International 2020 (October 22, 2020): 1–7. https://doi.org/10.1155/2020/3432987.
    Kaoutzanis, Christodoulos, Minqiang Xin, Tiffany N.S. Ballard, Kathleen B. Welch, Adeyiza O. Momoh, Jeffrey H. Kozlow, David L. Brown, Paul S. Cederna, and Edwin G. Wilkins. “Autologous Fat Grafting After Breast Reconstruction in Postmastectomy Patients: Complications, Biopsy Rates, and Locoregional Cancer Recurrence Rates.” Annals of Plastic Surgery 76, no. 3 (March 2016): 270–75. https://doi.org/10.1097/SAP.0000000000000561.

    Kronowitz, Steven J., Cosman Camilo Mandujano, Jun Liu, Henry M. Kuerer, Benjamin Smith, Patrick Garvey, Reshma Jagsi, Limin Hsu, Summer Hanson, and Vicente Valero. “Lipofilling of the Breast Does Not Increase the Risk of Recurrence of Breast Cancer: A Matched Controlled Study.” Plastic and Reconstructive Surgery 137, no. 2 (February 2016): 385–93. https://doi.org/10.1097/01.prs.0000475741.32563.50.

    Eichler, Christian, Jens Üner, Fabinshy Thangarajah, Julia Radosa, Max Zinser, Lotta Ada Fischer, Julian Puppe, Matthias Warm, Wolfram Malter, and Caroline Lenz. “Platelet-Rich Plasma (PRP) in Oncological Patients: Long-Term Oncological Outcome Analysis of the Treatment of Subcutaneous Venous Access Device Scars in 89 Breast Cancer Patients.” Archives of Gynecology and Obstetrics, April 4, 2022. https://doi.org/10.1007/s00404-022-06416-4.

    Since PRP has strong antibacterial qualities, and since those with breast cancer present a more inflammatory microbiota, the anti-bacterial effects may be partly responsible for the trend toward fewer recurrences.

    Urbaniak, Camilla, Gregory B. Gloor, Muriel Brackstone, Leslie Scott, Mark Tangney, and Gregor Reid. “The Microbiota of Breast Tissue and Its Association with Breast Cancer.” Edited by H. Goodrich-Blair. Applied and Environmental Microbiology 82, no. 16 (August 15, 2016): 5039–48. https://doi.org/10.1128/AEM.01235-16.

    More research regarding the O-Shot® procedure and dryness

    Saleh, Doaa M., and Rania Abdelghani. “Clinical Evaluation of Autologous Platelet Rich Plasma Injection in Postmenopausal Vulvovaginal Atrophy: A Pilot Study.” Journal of Cosmetic Dermatology n/a, no. n/a. Accessed March 9, 2022. https://doi.org/10.1111/jocd.14873.
    Samaie Nouroozi, Atefeh, Ashraf Alyasin, Ashraf Malek Mohammadi, Nili Mehrdad, Seyed Asadollah Mossavi, Mohammad Vaezi, atoosa Gharib, Ardeshir Ghavamzadeh, and Saeed Mohammadi. “Autologous Platelet-Released Growth Factor and Sexual Dysfunction Amendment: A Pilot Clinical Trial of Successful Improvement Sexual Dysfunction after Pelvic Irradiation.” Asian Pacific Journal of Cancer Prevention 20, no. 3 (March 1, 2019): 817–23. https://doi.org/10.31557/APJCP.2019.20.3.817.

    Zheng, Zhifang, Junfeiyang Yin, Biao Cheng, and Wenhua Huang. “Materials Selection for the Injection into Vaginal Wall for Treatment of Vaginal Atrophy.” Aesthetic Plastic Surgery 45, no. 3 (June 1, 2021): 1231–41. https://doi.org/10.1007/s00266-020-02054-w.

    Antibacterial Qualities of PRP

    Aggour, Reham L., and Lina Gamil. “Antimicrobial Effects of Platelet-Rich Plasma against Selected Oral and Periodontal Pathogens.” Polish Journal of Microbiology 66, no. 1 (April 3, 2017): 31–37. https://doi.org/10.5604/17331331.1235227.
    Cieslik-Bielecka, A., D. M. Dohan Ehrenfest, A. Lubkowska, and T. Bielecki. “Microbicidal Properties of Leukocyte- and Platelet-Rich Plasma/Fibrin (L-PRP/L-PRF): New Perspectives.” Journal of Biological Regulators and Homeostatic Agents 26, no. 2 Suppl 1 (2012).
    Sethi, Dalip, Kimberly E. Martin, Sangeeta Shrotriya, and Bethany L. Brown. “Systematic Literature Review Evaluating Evidence and Mechanisms of Action for Platelet-Rich Plasma as an Antibacterial Agent.” Journal of Cardiothoracic Surgery 16, no. 1 (September 28, 2021): 277. https://doi.org/10.1186/s13019-021-01652-2.
    Zhang, Wenhai, Yue Guo, Mitchell Kuss, Wen Shi, Amy L. Aldrich, Jason Untrauer, Tammy Kielian, and Bin Duan. “Platelet-Rich Plasma for the Treatment of Tissue Infection: Preparation and Clinical Evaluation.” Tissue Engineering. Part B, Reviews 25, no. 3 (June 1, 2019): 225–36. https://doi.org/10.1089/ten.teb.2018.0309

    Providers of the O-Shot® procedure<–

    Free info for possible providers of the O-Shot® procedure<–

    Apply for online training to provide the O-Shot® procedure<–

  • Research for Incontinence and for Better Sex

    Here’s new research about how to improve urinary continence in women…

    Click here to read the research<–

    So stress incontinence is a really serious problem that can affect your life and in ways that are sometimes difficult to deal with it, both in your personal and your business life. It can make it difficult to focus at work. It makes it difficult to get through a meeting, difficult to travel without stopping, it wakes you up at night, it makes it hard to exercise because you might be leaking urine and you’re not sleeping well so it makes it hard to feel rested during the day so it’s a significant problem and a lot of research going on trying to find an in between.

    The pills that you take can sometimes cause anticholinergics can cause trouble with constipation, trouble thinking and associated with dementia and surgery is a viable option but all of us would like to avoid surgery if we can. So here’s a really interesting study where they looked at successfully using autologous drive muscle STEM cells. Autologous muscle drives cells to grow, not STEM cells, but muscle drives cells to grow the bulk of the sphincter that helps a woman control her urine and actually it’s not a circumferential sphincter like a man, it’s more like a flap which makes it more difficult to hold urine and that flap is only a few cells thick so increasing the strength, just like you strengthen your bicep might help with that and that’s exactly what they showed; significant increase in sphincter volume as in a larger bicep muscle instead of larger sphincter volume or muscle to hold the urine in when compared with the placebo group.

    So check this out. It’s not something that’s mainstream yet as far as being able to offer but you might want to talk with an alternative which does something similar which is using PRP. In the athletic committees have sometimes even banned platelet rich plasma because not only does it heal tissue, but can add sometimes strength to the muscle.

    So it’s possible that one of the reasons our O-Shot is improving incontinence is because platelet rich plasma can increase the muscle strength as well as improve the health and the blood flow around the tissue. So a side effect could be improved sexuality response with orgasm or ability to have orgasm. So you might want to talk with your physician about this if they’re not a provider, there’s training on the website and we have a list of licensed providers on the website that are already trained, agreed to follow strict criteria and with the FDA approved devices.

    It’s not for everybody but that’s who I would contact to find out more information about this or talk with your physician about becoming certified or licensed to do the procedure. Hope you find it helpful and you’ll share this idea with your physician or with someone who might be suffering with incontinence.

    Find nearest O-Shot® provider

  • O-Shot® Helps Treat Lichen Sclerosus (more research)

    Here’s–once again–more, new, research showing benefit from treating lichen scelrosus with the O-Shot® procedure…

    **Platelet-rich plasma (PRP) for the treatment of vulvar lichen sclerosus in a premenopausal woman: A case report (this one with dramatic photos)<<click to read<—.

    **Rejuvenation Using Platelet-rich Plasma and Lipofilling for Vaginal Atrophy and Lichen Sclerosus (click to read)<–

    ** The use of PRP(platelet-rich plasma) in patients affected by genital lichen sclerosus: clinical analysis and results. <–click to read<==

    **The first study with biopsies showing benefit from PRP for lichen sclerosus (using the O-Shot® techniques). The dermatopathologists were blinded to the before and after treatments and benefit was shown…
    click to read<—(scroll to the next to last abstract)

    **More research about lichen sclerosus treatment with PRP
    click to read<–

    **Combining PRP with surgery for clitoral-hood phimosis from lichen sclerosus using O-Shot® techniques…
    Click to read<– (it’s on page S14)

    A video that shows more and gives some details…

    Find provider who will consider treating lichen sclerosus with PRP (RESULTS WILL VARY)…
    click<–(see the legend)

    Apply for training as a member of the O-Shot® provider group
    click<–(physicians and nurse practitioners)

    Women suffering with lichen sclerosus–Apply to participate in our on-going research
    click <–

  • Drs. Andrew Goldstein & Charles Runels Discuss O-Shot® Research

    Discussed in the Video…

  • Lichen Sclerosus Before & Afters

    Here’s an example of what is possible using O-Shot® methodology to treat lichen sclerosus. These photos are courtesy of Dr. Red Alinsod, who also enjoys a world-wide reputation for labial surgeries and is expert at freeing the phimosis that can happen with the clitoral hood.

    lichen-oshot-red-alinsod
    Possible results after treating lichen sclerosus with O-Shot® methodology.Courtesy of Dr.Red Alinsod

    Our Most Recent Research (click)<–

    Here’s where we are planning and raising money for future research (click)<–

    If you (or someone you love) suffers with lichen, then we will keep you updated with future research if you will give us your information on the following form (your information will not be shared). We will also send to you information occasionally about research that concerns vaginal and sexual health that may relate to subjects other than lichen (but which will be of importance to all women).

    Doctors may request more information about this methodology here (click)<–

    Because of the sexual nature of the emails (using words like “vagina” and displaying photos of the vagina) the spam filters will capture all of the communications to you unless you confirm that you wish to receive the information by clicking on the email that will be sent to you (which may also be in your spam folder).

    I hope and pray that we can eventually eliminate this horrible disease from the planet. Please help us in our quest by helping spread the word and by giving us your feed back.

    Patient Reviews (click)<–

    Here’s the form that allows us to keep you up-to-date and let you know about future research.
    All we really need is first name and email, but if you supply more it will help us identify you as a candidate for future research participation…

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