The following research showed that our O-Shot® techniques using PRP could decrease the chances of the development of squamous cell carcinoma in women suffering from lichen sclerosus.
Over a period of about nine years, none of the 319 women followed developed squamous cell carcinoma after treatment with PRP.
=>Here’s the research to read as a pdf<–
=>Where to find a physician offering the procedure in your area<–
-> Where your physician can find more information (click) about the procedure (the web page you are reading now is only for education; your physician (in consultation with you) can best determine your treatment.
-> Here’s where you can calculate your Female Sexual Function Index (free online test)<–
Here’s more research about PRP and it’s benefit for lichen sclerosus…
- Casabona, Francesco, Ilaria Gambelli, Federica Casabona, Pierluigi Santi, Gregorio Santori, and Ilaria Baldelli. “Autologous Platelet-Rich Plasma (PRP) in Chronic Penile Lichen Sclerosus: The Impact on Tissue Repair and Patient Quality of Life.” International Urology and Nephrology 49, no. 4 (April 2017): 573–80. https://doi.org/10.1007/s11255-017-1523-0.
- Casabona, Francesco, Virginia Priano, Valerio Vallerino, Angela Cogliandro, and Giorgio Lavagnino. “New Surgical Approach to Lichen Sclerosus of the Vulva: The Role of Adipose-Derived Mesenchymal Cells and Platelet-Rich Plasma in Tissue Regeneration.” Plastic and Reconstructive Surgery 126, no. 4 (2010): 210e–11.
- Cattaneo, A., P. Carli, A. De Marco, L. Sonni, G. Bracco, A. De Magnis, and G. L. Taddei. “Testosterone Maintenance Therapy. Effects on Vulvar Lichen Sclerosus Treated with Clobetasol Propionate.” The Journal of Reproductive Medicine 41, no. 2 (February 1996): 99–102.
- Chin, Simone, James Scurry, Jennifer Bradford, Geoffrey Lee, and Gayle Fischer. “Association of Topical Corticosteroids With Reduced Vulvar Squamous Cell Carcinoma Recurrence in Patients With Vulvar Lichen Sclerosus.” JAMA Dermatology 156, no. 7 (July 1, 2020): 813–14. https://doi.org/10.1001/jamadermatol.2020.1074.
- Franic, D., Z. Iternička, and M. Franić-Ivanišević. “Platelet-Rich Plasma (PRP) for the Treatment of Vulvar Lichen Sclerosus in a Premenopausal Woman: A Case Report.” Case Reports in Women’s Health 18 (April 2018): e00062. https://doi.org/10.1016/j.crwh.2018.e00062.
- Garrido-Colmenero, Cristina, Carmen María Martínez-Peinado, Manuel Galán-Gutiérrez, Virginia Barranco-Millán, and Ricardo Ruiz-Villaverde. “Successful Response of Vulvar Lichen Sclerosus with NB-UVB.” Dermatologic Therapy 34, no. 2 (2021): e14801. https://doi.org/10.1111/dth.14801.
- Goldstein, Andrew T., Michelle King, Charles Runels, Meghan Gloth, and Richard Pfau. “Intradermal Injection of Autologous Platelet-Rich Plasma for the Treatment of Vulvar Lichen Sclerosus.” Journal of the American Academy of Dermatology 76, no. 1 (January 2017): 158–60. https://doi.org/10.1016/j.jaad.2016.07.037.
- Goldstein, Andrew T., Leia Mitchell, Vaishnavi Govind, and Debra Heller. “A Randomized Double-Blind Placebo Controlled Trial of Autologous Platelet Rich Plasma Intradermal Injections for the Treatment of Vulvar Lichen Sclerosus.” Journal of the American Academy of Dermatology, January 2019. https://doi.org/10.1016/j.jaad.2018.12.060.
- Goodchild, Sophie. “How Kim Kardashian’s Vampire Facial Could Provide Relief to 1m Women.” Mail Online, November 5, 2022. https://www.dailymail.co.uk/health/article-11393613/How-Kim-
- Kardashians-vampire-facial-provide-relief-1m-British-women.html.
- Gulin, Sandra Jerkovic, Filippa Lundin, and Oliver Seifert. “Comorbidity in Patients with Lichen Sclerosus: A Retrospective Cohort Study.” European Journal of Medical Research 28, no. 1 (September 11, 2023): 338. https://doi.org/10.1186/s40001-023-01335-9.
- Gunthert, A.R., K. Duclos, B.G. Jahns, and et al. “Clinical Scoring System for Vulvar Lichen Sclerosus.” J Sex Med 9 (2012): 2342–50.
- Gutierrez-Ontalvilla, P., F. Giner, L. Vidal, and M. Iborra. “The Effect of Lipofilling and Platelet-Rich Plasma on Patients with Moderate-Severe Vulvar Lichen Sclerosus Who Were Non-Responders to Topical Clobetasol Propionate: A Randomized Pilot Study.” Aesthetic Plastic Surgery 46, no. 5 (October 2022): 2469–79. https://doi.org/10.1007/s00266-021-02718-1.
- Krogh, G von, K Dahlman-Ghozlan, and S Syrjänen. “Potential Human Papillomavirus Reactivation Following Topical Corticosteroid Therapy of Genital Lichen Sclerosus and Erosive Lichen Planus.” Journal of the European Academy of Dermatology and Venereology : JEADV 16, no. 2 (March 2002): 130–33. http://www.ncbi.nlm.nih.gov/pubmed/12046814.
- Lee, A., J. Bradford, and G. Fischer. “Long-Term Management of Adult Vulvar Lichen Sclerosus: A Prospective Cohort Study of 507 Women.” JAMA Dermatol 151 (2015): 1061–67.
- Marnach, Mary L., and Rochelle R. Torgerson. “Therapeutic Interventions for Challenging Cases of Vulvar Lichen Sclerosus and Lichen Planus.” Obstetrics & Gynecology 138, no. 3 (September 2021): 374–78. https://doi.org/10.1097/AOG.0000000000004498.
- Mitchell, Leia, Andrew T. Goldstein, Debra Heller, Theodora Mautz, Chelsea Thorne, So Yeon Joyce Kong, Maria E. Sophocles, Hillary Tolson, and Jill M. Krapf. “Fractionated Carbon Dioxide Laser for the Treatment of Vulvar Lichen Sclerosus: A Randomized Controlled Trial.” Obstetrics & Gynecology 137, no. 6 (June 2021): 979–87. https://doi.org/10.1097/AOG.0000000000004409.
- “New Surgical Approach to Lichen Sclerosus of the Vulva: The Role of Adipose-Derived Mesenchymal Cells and Platelet-Rich Plasma in Tissue Regeneration. Casabona F1, Priano V.” Plast Reconstr Surg., n.d.
- Origoni, M., D. Ferrari, M. Rossi, F. Gandini, M. Sideri, and A. Ferrari. “Topical Oxatomide: An Alternative Approach for the Treatment of Vulvar Lichen Sclerosus.” International Journal of Gynecology & Obstetrics 55, no. 3 (December 1996): 259–64. https://doi.org/10.1016/S0020-7292(96)02768-3.
- Pensato, Rosita, and Simone La Padula. “The Effect of Lipofilling and Platelet-Rich Plasma on Patients with Moderate–Severe Vulvar Lichen Sclerosus Who Were Non-Responders to Topical Clobetasol Propionate: A Randomized Pilot Study.” Aesthetic Plastic Surgery, May 31, 2022. https://doi.org/10.1007/s00266-022-02947-y.
- Posey, Kathleen, and Charles Runels. “In-Office Surgery and Use of Platelet Rich Plasma for Treatment of Vulvar Lichen Sclerosus to Alleviate Painful Sexual Intercourse.” Journal of Lower Genital Tract Disease 19, no. 3 (July 2015): S1–25. https://doi.org/10.1097/lgt.0000000000000121.
- Qing, Chun, Xiaoyong Mao, Gaoqing Liu, Yibin Deng, and Xiaokun Yang. “The Efficacy and Safety of 5-Aminolevulinic Acid Photodynamic Therapy for Lichen Sclerosus: A Meta Analysis.” Indian Journal of Dermatology 68, no. 1 (2023): 1–7. https://doi.org/10.4103/ijd.ijd_925_21.
- Tedesco, M., G. Pranteda, G. Chichierchia, and et al. “The Use of PRP (Platelet-Rich Plasma) in Patients Affected by Genital Lichen Sclerosus: Clinical Analysis and Results.” J Eur Acad Dermatol Venereol 33 (2019): e58–59.
- Vittrup, G., L. Mørup, T. Heilesen, D. Jensen, S. Westmark, and D. Melgaard. “The Quality of Life and Sexuality in Women with Lichen Sclerosus – A Cross Sectional Study.” Clinical and Experimental Dermatology n/a, no. n/a. Accessed August 31, 2021. https://doi.org/10.1111/ced.14893.
