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Should I Add Testosterone to My O-Shot® Procedure?
Charles Runels, MD Avatar
Charles Runels, MD

Here is the Medscape article to which I refer in the video<–

Here’s a transcript of this video<–

Research about Testosterone in Women

Cattaneo, A., P. Carli, A. De Marco, L. Sonni, G. Bracco, A. De Magnis, and G. L. Taddei. “Testosterone Maintenance Therapy. Effects on Vulvar Lichen Sclerosus Treated with Clobetasol Propionate.” The Journal of Reproductive Medicine 41, no. 2 (February 1996): 99–102.
Cellai, I., S. Filippi, P. Comeglio, S. Cipriani, E. Maseroli, V. Di Stasi, T. Todisco, et al. “Testosterone Positively Regulates Vagina NO-Induced Relaxation: An Experimental Study in Rats.” Journal of Endocrinological Investigation 45, no. 6 (June 2022): 1161–72. https://doi.org/10.1007/s40618-022-01743-4.
Davis, Susan R, and Glenn D Braunstein. “Efficacy and Safety of Testosterone in the Management of Hypoactive Sexual Desire Disorder in Postmenopausal Women.” The Journal of Sexual Medicine 9, no. 4 (April 2012): 1134–48. https://doi.org/10.1111/j.1743-6109.2011.02634.x.
Glaser, Rebecca, Constantine Dimitrakakis, Nancy Trimble, and Vincent Martin. “Testosterone Pellet Implants and Migraine Headaches: A Pilot Study.” Maturitas 71, no. 4 (April 2012): 385–88. https://doi.org/10.1016/j.maturitas.2012.01.006.
———. “Testosterone Pellet Implants and Migraine Headaches: A Pilot Study.” Maturitas 71, no. 4 (April 2012): 385–88. https://doi.org/10.1016/j.maturitas.2012.01.006.
Maseroli, Elisa, and Linda Vignozzi. “Testosterone and Vaginal Function.” Sexual Medicine Reviews 8, no. 3 (July 2020): 379–92. https://doi.org/10.1016/j.sxmr.2020.03.003.
Mitsui, Yozo, Fumito Yamabe, Shunsuke Hori, Masato Uetani, Hiroshi Aoki, Kei Sakurabayashi, Mizuho Okawa, Hideyuki Kobayashi, Koichi Nakajima, and Koichi Nagao. “Significant Inverse Association of Testosterone Level with Penile Deformity Severity in Japanese Males with Peyronie’s Disease.” International Journal of Urology: Official Journal of the Japanese Urological Association 30, no. 1 (January 2023): 36–42. https://doi.org/10.1111/iju.15055.
Parish, Sharon J., James A. Simon, Susan R. Davis, Annamaria Giraldi, Irwin Goldstein, Sue W. Goldstein, Noel N. Kim, et al. “International Society for the Study of Women’s Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women.” The Journal of Sexual Medicine 18, no. 5 (May 2021): 849–67. https://doi.org/10.1016/j.jsxm.2020.10.009.
———. “International Society for the Study of Women’s Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women.” The Journal of Sexual Medicine 18, no. 5 (May 2021): 849–67. https://doi.org/10.1016/j.jsxm.2020.10.009.
Pinkerton, JoAnn V., Isabella Blackman, Edward Alexander Conner, and Andrew M. Kaunitz. “Risks of Testosterone for Postmenopausal Women.” Endocrinology and Metabolism Clinics of North America 50, no. 1 (March 2021): 139–50. https://doi.org/10.1016/j.ecl.2020.10.007.
“Practice Knowledge Base – 1. Testosterone & Estradiol – All Documents,” November 14, 2022. https://biotemedical.sharepoint.com/sites/KnowledgeBase/Clinic%20Knowledge%20Base/Forms/AllItems.aspx?ga=1&id=%2Fsites%2FKnowledgeBase%2FClinic%20Knowledge%20Base%2FStudies%2F1%2E%20Testosterone%20%26%20Estradiol&viewid=c69e829b%2Db588%2D4d3a%2D9864%2Db1bb6fcfeaa6.
Rooij, Kim van, Saskia Poels, Jos Bloemers, Irwin Goldstein, Jeroen Gerritsen, Diana van Ham, Frederiek van Mameren, et al. “Toward Personalized Sexual Medicine (Part 3): Testosterone Combined with a Serotonin1A Receptor Agonist Increases Sexual Satisfaction in Women with HSDD and FSAD, and Dysfunctional Activation of Sexual Inhibitory Mechanisms.” The Journal of Sexual Medicine 10, no. 3 (March 2013): 824–37. https://doi.org/10.1111/j.1743-6109.2012.02982.x.
Rooij, Kim van, Saskia Poels, Petra Worst, Jos Bloemers, Hans Koppeschaar, Andrew Goldstein, Berend Olivier, and Adriaan Tuiten. “Efficacy of Testosterone Combined with a PDE5 Inhibitor and Testosterone Combined with a Serotonin (1A) Receptor Agonist in Women with SSRI-Induced Sexual Dysfunction. A Preliminary Study.” European Journal of Pharmacology 753 (April 15, 2015): 246–51. https://doi.org/10.1016/j.ejphar.2014.10.061.
Sicotte, Nancy L., Barbara S. Giesser, Vinita Tandon, Ricki Klutch, Barbara Steiner, Ann E. Drain, David W. Shattuck, et al. “Testosterone Treatment in Multiple Sclerosis: A Pilot Study.” Archives of Neurology 64, no. 5 (May 2007): 683–88. https://doi.org/10.1001/archneur.64.5.683.
Sideri, M., M. Origoni, L. Spinaci, and A. Ferrari. “Topical Testosterone in the Treatment of Vulvar Lichen Sclerosus.” International Journal of Gynecology & Obstetrics 46, no. 1 (July 1994): 53–56. https://doi.org/10.1016/0020-7292(94)90309-3.
Tordoff, Diana M., Mitchell R. Lunn, Bertha Chen, Annesa Flentje, Zubin Dastur, Micah E. Lubensky, Matthew Capriotti, and Juno Obedin-Maliver. “Testosterone Use and Sexual Function among Transgender Men and Gender Diverse People Assigned Female at Birth.” American Journal of Obstetrics and Gynecology, September 5, 2023, S0002-9378(23)00605-1. https://doi.org/10.1016/j.ajog.2023.08.035.
Vignozzi, Linda, Sandra Filippi, Annamaria Morelli, Paolo Comeglio, Ilaria Cellai, Erica Sarchielli, Elena Maneschi, et al. “Testosterone/Estradiol Ratio Regulates NO‐Induced Bladder Relaxation and Responsiveness to PDE5 Inhibitors.” The Journal of Sexual Medicine 9, no. 12 (December 2012): 3028–40. https://doi.org/10.1111/j.1743-6109.2012.02946.x.

 

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