**The first study with biopsies showing benefit from PRP for lichen sclerosus (using the O-Shot® techniques). The dermatopathologists were blinded to the before and after treatments and benefit was shown… click to read<—(scroll to the next to last abstract)
**More research about lichen sclerosus treatment with PRP click to read<–
**Combining PRP with surgery for clitoral-hood phimosis from lichen sclerosus using O-Shot® techniques… Click to read<– (it’s on page S14)
A video that shows more and gives some details…
Find provider who will consider treating lichen sclerosus with PRP (RESULTS WILL VARY)… click<–(see the legend)
Story and photos courtesy of… João Brito Jaenisch Neto
Dr. João Brito Jaenisch Neto
42 years old with 2 vaginal childbirth. Came in to office complaining with vaginal itch, burning and white vaginal discharge.
Physical examination: I saw this issues and took pictures.
before treatment
I told her that her symptoms were from the acute and severe fungus , yeast, candidíase. I told her that I would like to treat her with PRP to repair the tissues damages and just oral cetoconazol for 5 days.
I never ever had such amazing tissues restore. I did PRP in all damage tissue area. She came back 7 days later and the outcome was the pictures.
NO VAGINAL CREAM.
João Brito Jaenisch Neto (click to see his clinic)<–
4. What are the health risks of undergoing the procedure?
5. Is there any data on how many people undergo this procedure in the U.S.?
6. How rare/common are incidents like the one that occurred in New Mexico?
7. Why did it occur?
Important Notice from the Cellular Medicine Association–the recent incident in New Mexico took place at a center illegally using our name (Vampire Facial®). Qualified medical professionals handle blood all day long without serious problems and this procedure is even safer since it’s done with the patient’s own blood. But done improperly–people can be killed by cross-contamination. The providers in this article were imposters.
This is the official website to find those who have been certified to do the procedure by the Cellular Medicine Association and where you can read the research–click to see our directory<– Providers found there agreed to use devices approved by the FDA to both prepare the blood and to do the micro-needling. Anyone advertising the Vampire Facial® who is not listed there is stealing intellectual property and cannot be trusted. See PubMed & our website for more research
The Vampire Facial® name is owned by Charles Runels (see the website for the US Patent & Trademark office), although the name is currently under attack by those who would want free use of the name to sell devices and procedures without regard for our standards.
Someone using the name —as described in this article (click)—to trick people is exactly like someone making a fake Tylenol bottle and putting poison in it. Please—buyer beware! Only providers listed on our official website should be trusted to do the procedure.
Woman dies in the office of a massage therapist advertising the Vampire Facelift® (if you read the article, you’ll see the person actually died from a buttocks injection of something other than blood (probably something from the hardware store–NOT from a Vampire Facelift®). This woman would have never been accepted into our provider group and was using our name illegally.
Full Transcript of Video & Link to Published Research Follows…
Charles Runels: Let’s talk about something that I hate, I really hate, it’s dyspareunia or pain with sexual intercourse in women who are already suffered from breast cancer. Imagine the loneliness of having already gone through all the treatments for breast cancer, and now that you’ve survived, and you’ve lived through radiation, perhaps chemotherapy, perhaps surgery, and now you’re left with the inability to use estrogens that are needed to maintain the lubrication that’s involved with comfortable, sexual, intercourse.
Unlike decreased arousal, where a woman who loves her husband can accommodate, or decreased orgasm, where a woman can still enjoy sexual intercourse without orgasm, dyspareunia makes a woman actually avoid her husband. Her fear is often that if she arouses the husband, then the husband becomes more frustrated. I hear of women who will even avoid touching or holding their husband’s hand, even though she loves him, because of fear of arousing him, and then causing frustration because they can’t have sex. The things that have been tried for this … The thing is, it separates lovers.
Now, who am I? My name is Charles Runels; I’m the inventor of the O-Shot® Procedure, so I’ll just tell you right now, we’re coming to talking about how that might be a solution to this problem. I’ve been treating women for sexual dysfunction for the past 18 years. I’ve been a physician for 20 plus years, and I’ve done research in the area and I think we have something to help maybe.
But let’s go ahead and talk more about what’s been tried, and we’ll get to what’s new. If you look at a search on PubMed, which is the main way for finding research that physicians use worldwide. If you look at the different solutions that come up, not a lot of research in general, when you search dyspareunia and breast cancer, but if you look at the answers, it’s really very frustrating.
The conclusion of this one is, “Breast cancer survivors with menopausal dyspareunia …” In other words, they cannot use estrogens for fear of recurrence of the breast cancer … “can have comfortable intercourse after applying liquid lidocaine.” So, she’s back to accommodating, but not necessarily enjoying, and I’m not saying this is a horrible thing, it doesn’t mean it’s not something that can be used. But, if you look at the research that’s shown here, it involves basically, numbing things. It can get on her lover, and so they both can now put their genitals together which allow some closeness, but it really doesn’t allow the pleasure of sex, like it could be if you just made the pain go away instead of numbing it down.
So you look at this other one. Look at what they’re recommending here … Aqueous lidocaine. Not so good. These are the most relevant searches for this problem. If you look at this one, “Olive oil, exercises, and moisturizers.” So, when it comes right down to it, it’s a long way of saying that the current best practices are a combination of lubricating, numbing, and some sort of counseling. Counseling as in learning how to stay close without the pleasure of sexual intercourse.
My hats off to all the research that’s gone into finding a solution. I’m not angry at the solutions or the people that have tried to find these solutions. I’m very angry that this is the best we have. Starting about eight years ago, I started using Platelet Rich Plasma (PRP), first to inject Platelet Rich Plasma into the genital-urinary space, and we published some research about that, which you can find if you go to O-Shot®.info or O-Shot®.com, it wants … Puts you on the same web page, and then click on research. When you click on the research, you’ll see a list of various things that can be done to help with sexual dysfunction, and other problems secondary to that effect … Wait a minute … Then, at the top of that, you’ll see a paper that we publish, this is me, and we talk about all the reasoning why using Platelet Rich Plasma maybe of help, and we showed that we were able to decrease female sexual distress significantly, extremely significantly by using Platelet Rich Plasma to cause rejuvenation of the tissue. Platelet Rich Plasma has been demonstrated in multiple studies. Look at how many studies you have with Platelet Rich Plasma. Over 10,000 the last time I looked.
Yeah, there you go. 9,987 papers about Platelet Rich Plasma. This is not some new thing, and they go back over 20 years. It’s been known to help with healing of hard-to-heal tissue. The dentists have used it quite a bit. Orthopedic surgeons are trying to heal. Both of those specialties have to heal bone and cartilage, with not a good blood supply. And so it’s been used in that arena, and in 2010 I started using it for the vaginal periurethral space, and we published this study soon after that.
Now, there’s a new … We’ve been seeing this help for the past eight years, but a new study came out supporting it, and I want to get to demonstrate and talk more about what they did with this study, where they used Platelet Rich Plasma combined with hyaluronic acid for the treatment of vulva vaginal atrophy in post-menopausal women. You can see here they did not …. It wasn’t just about the atrophy. They followed dyspareunia, and saw female sexual distress improved significantly with that treatment. I propose that it would have improved much, much more had they used our protocol. But still, it was statistically significant. So we’re back to my protocol, but let’s … Let me break this down to what we initially did in our study, so that you can understand what they did.
In the study that we did, we took the Platelet Rich Plasma and then … which you get by doing a centrifuge, and then the centrifuge separates out Platelet Rich Plasma from the red cells, and I can show you a picture of what that looks like right here. So you start off with a tube that looks like just a tube full of blood, has an anticoagulant in it, and then when you get through with the centrifuge, you’ll have red cells at the bottom, but instead of a buffy coat and platelets on top of it, and plasma on top of it, there’s a gel that separates them so that now they’ll remove the plasma and inject it into the area. So, it mimics what happens every time you have surgery or injury. This is not a new idea, it happens every time you have to heal a wound that the platelets release growth factors, and then those growth factors cause recruitment and activational plural potent stem cells that migrate from the bone marrow and heal the tissue.
This is very well known in the orthopedic and dental space, so much so that it’s quit being about whether it works or not, it’s the best way to use it. You can see here’s one from the National Journal of Implant Dentistry, where looking at using calcium chloride to activate the Platelet Rich Plasma. Now, what does activation means of this FDA approved, and what does this all mean?
Your blood does not require approval by the FDA. It’s your blood. Just like your saliva, your hair and your skin. But if you’re going to isolate a part of the blood for re-injection to a human body, you should use a device that’s FDA approved for that purpose. Those devices vary based upon method that isolates the platelets and how the platelets are activated. For example, this one uses a gel that I just showed you, and to separate it. But others use filters, and double centrifuges and pipe fitting techniques and all sorts of things, so, that’s not the only way to do it. This one has a gel that separates. There’s the gel … the red cells from the plasma, and then the plasma’s re-injected.
Activation is widely accepted within the orthopedic and dental literature as being helpful, because it tells the platelets to release all those growth factors. That activation can be done with vacuum, calcium chloride, calcium gluconate, and with a hyaluronic acid filler, like Juvederm or the orthopedic versions, like Hyalgan, because the platelets interpret that to being a form of collagen, which causes the platelets to release those growth factors and cytokines.
This particular kit has a small amount of hyaluronic acid, which is again like a Juvederm, or Restylane, or Hyalgan, or Synvisc, or all hyaluronic acids, that comes with the kit, there are other kits that come with calcium chloride. Some kits don’t come with anything, and you have to add the calcium chloride or the calcium gluconate, or the HA yourself. So, this kit was sponsored by a company that makes a kit … Region makes a kit, that comes with an HA. The point I’m making is that there’s really two variables here, right? They’re injecting two things. Platelet concentrate, which they’re calling … That’s the word they’re using for Platelet Rich Plasma, and hyaluronic acid. That’s two different variables. So, don’t let that confuse you though, because the HA is just a way of activating, and you never cause rejuvenation of tissue of any significant degree with an HA, although there is a mild effect. The major effect is from Platelet Rich Plasma.
Now, how do I know this, and what’s my background? In addition to inventing the O-Shot®, also invented the Vampire Facelift®. This was something that most people don’t know, but when I was experimenting this, which Kim Kardashian did, and many celebrities have now done, when I was inventing this, I was actually doing this as a way to figure out how to use it in the genital-urinary space. Now, of course out of it came a useful cosmetic procedure, but as a wound care physician, I had already been looking at this in other arenas. For example, this one. Where PRP is used in combination with a HA for healing a wound, and others like it, where … But others like it, for example this one. Using PRP combined with an HA, and it helps heal wounds. But it’s the PRP that’s active and you have many, many studies showing PRP as a stand-alone for healing wounds.
So, if you go to PubMed and you put in Platelet Rich Plasma, and then you put wounds behind it, or wound healing, you get lots of stuff and most of these don’t use an HA as part of the process. And you can see it’s all about it heals muscle, there’s collagen, there’s new blood flow, and so it’s really a very well-documented way of regenerating tissue, all tissue types, nerve, blood flow, collagen, even fat cells.
There are 1,700 studies. Back to what we’re doing here with the dyspareunia secondary to dryness from lack of hormones, particularly estrogen, in the case of someone who’s had breast cancer, what we’re doing is using the PRP to recruit plural potent stem cells that grow the new tissue, and the HA as an activator. Go into more detail about what the studies show. They measured vaginal health index, which you can see I said that ought to do with fluid, the PH, the moisture, and they did a Xylocaine cream, but we use a Bupivacaine/Lidocaine/Tetracaine cream that works I think better than this. So, our pain ratio would be different. They injected four CCs in the vestibule in the first three centimeters of the vagina using a point-by-point technique. This is not needed. This would hurt more, because you … PRP spreads so easily through the tissue. You don’t have to do so many injection points. In the posterior vaginal wall, and the posterior wall of the introitus.
You can see here where they’re putting the injections. The thing about this is that it’s missing out on the anterior wall. Now, why would they skip the anterior wall? The reason is that there are multiple studies showing that HAs in the anterior vaginal wall, hyaluronic acid in the anterior vaginal wall can cause granulomas, it can lead to obstruction. That’s not a good thing. But by leaving out the anterior vaginal wall, you miss rejuvenating the Skene’s glands of the periurethral glands. Let me show you where those live.
If you look at the cross-section through the vagina and urethra, the Skene’s glands or the periurethral glands are very near the opening here on the front side of the vagina. So, if you’re doing all the injections back here, it’s not going to do anything with that. So, why is that important? Why is the Skene’s glands or the periurethral glands important?
Actually, let me get this where you can see it better. Here’s the urethra, here’s the vagina, here’s the periurethral glands or the Skene’s glands. Here’s another picture of it showing you where it may open up just near the opening of the urethra. Here’s another view of it, showing the Skene’s glands are right there, all of it on the front side, but these guys if you go back and look are injecting on the back side. That’s not a bad thing, they help the woman, but it’s a less than it could be thing. Now, had they injected the anterior vaginal wall, actually my feeling is that there’s not enough HA in that particular kit to cause a problem. I’ve used it, it’s a good kit, I don’t think it’s enough to cause a problem.
But, I don’t know that I’d want to risk it in someone without a study showing that I’m not going to see granulomas, like [Swissman 00:16:15] demonstrated before. So, when we do our O-Shot®, we inject PRP here, but we do not use an HA, so we use a PRP that’s activated with calcium chloride, like we talked about over here, using calcium chloride instead of an HA to activate. Back to our study, when they did this they activated with an HA and now these platelets have released their growth factors, we don’t even care about the platelets anymore, the growth factors are in the plasma, and that’s what gets injected here, after it’s been activated.
If you look what happens, it’s pretty spectacular that the effect of it … Now, this is PH and vaginal health, and you can see it levels off at about three months, which is what you see in most soft tissue studies. When they ask the women would you like to repeat it, 19 out of 20 of them said that they would. But then if you go back and you think well wow, what if they would have actually injected here, just like the men’s prostrate excretes a lot of fluid, it’s the main thing that makes the fluid when a man ejaculates, a woman’s Skene’s glands do as well. We actually have women who ejaculate for the first time after using PRP in the anterior vaginal wall. I think they miss some of the benefits. When we did our study, we had a larger improvement of female sexual distress than they did … they saw with their study.
But, I’m still very grateful. It’s a good study that shows that PRP with an HA can help, but I’m telling you, we’ve been doing it for eight years, and PRP injected the way we do with our O-Shot® does more than an improvement … The improvement in the female sexual distress that was shown here. So what the heck is the female sexual distress scale? This is what it looks like. You can see the most you could get … The more of the … All these questions, 13 questions are answered, and each question has a maximum of four, with a higher score means you’re having more problems. So, if you’re worried about your sex not at all, it gets a zero, all the time gets a four. So, the most you could get was four times 13 and we were able to see a large percentage of our people go from distressed to not distressed when we used PRP the way we do with the O-Shot®, which is anterior vaginal wall and the clitoris.
It’s a really important study. I think it backs up what we’re doing. But, I think that we have a better technique that we can use. I think if you want to know more about it as a patient, you would go to our O-Shot® website, which you just type in O-Shot®.com, or dot info either way, it gets you there. O-Shot®.com. Then, when you’re there, if you click on … You could read all about it. Read the research. You could see if you go to research thing here, you can see me covering other research projects that have to do with what we’ve done like in necrosis, urinary incontinence, all sorts of things. There’s a chapter about it in this textbook, and you can see some lectures where I’ve lectured various places.
That’s the place to read the research. If you want to see one of our providers, almost every page has a place on it somewhere that says that. Click here to find provider, and then once you’re there just click on your country, or your state and it will show you people in that area, or if you give it permission to know where you are, it will just show them nearest to farthest away. So, we have multiple countries, and multiple states here. So almost every state, and 50-something countries. Now, if you’re looking for someone who does other things, like treats lichen, use radio frequency, a laser, or has Emsella machine, then you’ll see those icons by their name as an indication that they treat that. So, this doctor for example uses laser and treats Lichen Sclerosus. This means that they’re a teacher for us, and I think that’s all you need to know. That’s where you go obviously, nothing works all the time ever, ever. Results do vary, so you should speak with your physician and speak with one of our physicians about being treated this way.
Now, if you’re a physician, you go here, under physicians and there’s a place to get free information. You just fill this out, and we’ll send it to you. Tell me where your office is, and you can get any kind of free information you want. If you actually want to go ahead and apply for either online or hands-on training, you go to O-Shot®.info/members, and that’s where we list a place for you to apply to become a member of our provider group. We have a very specific way of doing this. As you can see, [inaudible 00:21:22] every way that you inject PRP matters, and we have a very specific method that we teach. As a matter of fact, if you don’t see someone listed on our directory, then they’re not licensed to use our name, and they may be doing something better, but more likely they’re doing something not as effective. I highly recommend you use someone off of this list, and if someone’s using our name O-Shot® and not on this list, they’re pretending to be part of our group when they’re not. So, you can make your own conclusions about what that means morally.
Anyway, here’s where you would apply, O-Shot®.info/members, if you’re interested in being part of us. This is under the umbrella of the Cellular Medicine Association, where we do research. We spend hundreds of thousands of dollars every year researching the areas of female and male sexual dysfunction. We have teachers around the world. We also have online training that you can apply for. I hope that’s helpful to you. I think this is really important research, and I’m very grateful to these guys for doing this. But, there’s a lot more to know and we would love to help you learn more about it, whether you’re a teacher or a provider. Thank you very much for your attention.
48 year old G5P2 perimenopausal female presents with menorrhagia, uterovaginal prolapse and urinary incontinence. Patient demonstrated stress urinary incontinence on formal urodynamics testing (Laborie Medical). During preoperative counseling, patient expressed she did not want to have any polypropylene sling placed. Discussed the injection of platelet rich plasma (O Shot) and patient signed formal consent.
She underwent an uncomplicated robotically assisted total laparoscopic hysterectomy with anterior and posterior colporrhaphy. Patient’s blood was harvested and centrifuged utilizing the Stryker Vitagel kit. During the last step of the procedure, cystoscopy was performed (Figure 1) with a 30-degree cystoscope (Stryker). 4 cc of platelet rich plasma with 0.2 cc of 10% of CaCl was injected 1” from hymenal ring with 27 Gauge needle and 1 cc of platelet rich plasma with 0.05 of 10% of CaCl was injected into the clitoris.
5 minutes after the O shot was performed, a 30-degree cystoscope was inserted again which revealed ureteral jets bilaterally as well as the view of the urethral sphincter shown in Figure 2.
Postoperatively, patient came back to my office 1 week later. She did not have any urinary leakage and was satisfied with the outcome. Shown in Figure 3 and Figure 4 are before and after of the vaginoplasty.
These images are available in my realself.com gallery
Patient has signed permission to use her images as long as she was deidentified. This release waiver is signed and filed in my office.
Urethral Bulking for Female Stress Urinary Incontinence
There have been similar results described in the literature with synthetic soft tissue bulking agents such as Macroplastique. One of the side effects, however is granuloma formation.
Future
This case has inspired me to use formal urodynamics study how the urethral pressures change during the placement of platelet rich plasma in the Grafenberg spot. Using wireless Bluetooth catheters may quantify and guide to clinician with greater accuracy on where (and possibly how much) volume of platelet rich plasma to inject for optimal result with regard to treating urinary incontinence.
This recording is to help you understand what to expect after the O-Shot® (also called the Orgasm Shot®) procedure.
Hello, my name is Charles Runels and I’m honored to talk with you about the procedure. During this recording, we’ll discuss interstitial cystitis, chronic mesh pain, the appearance of the labia majora, lichen sclerosus, lichen planus, dyspareunia, incontinence, both stress and urge, orgasm and difficulty with orgasm, both with masturbation and with penis and vagina sex. That’s a lot, so let’s get started.
First of all, my thanks to the amazing people in our group. The Cellular Medicine Association governs the quality of provider, helps curate the information that’s provided, and the observations that are seen by the members of our group. The Cellular Medicine Association helps finance research, and much of what I’m giving to you now has been gleaned from the amazing physicians and nurse practitioners in that group.
Blood is not governed by the FDA. The Food and Drug Administration governs food and drugs and devices. They don’t govern blood, but the members of our group have agreed to use a device that is approved by the FDA to prepare the plasma that’s used in the O-Shot or the Orgasm Shot. You should have had the procedure done by someone in our group. This is not just a shot to be done any way that might occur to someone. The structures around the urethra are very intricately and amazingly put together. The results can vary tremendously based on where the injection is placed, both in not only the results, but also the comfort can be completely pain-free or it could be excruciatingly painful depending on the skillset of the person doing it and their understanding of what it is we do. Be sure that that is done, and if you have a not so good experience, that you report your experience, good or bad, to the Cellular Medicine Association.
There is a blog on the O-Shot website, and there’s also a survey that can be done for free, to help us understand what happens with people who have the procedure done. Request that your provider enroll you in that survey, which is done in a very private way using two HIPAA compliant, double password protected and very, very secure servers that never ask you for your name. That’s not obligated. You’re not obligated to participate, but we hope that you will, and all the members in our group have that capability to help us understand what’s going on and how to further develop this.
There’s been over 9,000 papers published in PubMed about platelet-rich plasma, and thus far, none of those research papers have demonstrated any severe infections or damage done from platelet-rich plasma, which is what you would expect since platelet-rich plasma is what the body uses to heal tissue. On the other hand, that doesn’t mean that everything works out perfectly and that there are no side effects, so we should talk about that.
A review of some of the research (transcript continues below)…
First of all, in general, the plasma will go away after about nine days. The platelet-rich plasma contains platelets, which act like suitcases to carry growth factors and cytokines, over 20 of them, that then recruit stem cells from the bone marrow that come to the area and heal new tissue. Research has shown that platelet-rich plasma can help heal scars, help fight infection, down regulate the autoimmune response, help regrow new nerve. That’s been demonstrated in multiple studies, like I said, over 9,000 studies in wounds healing, in dentistry and surgery over the past 15 years. We are applying that research in the area of the genitourinary space.
In general, and what we have seen in this procedure is that the plasma goes away at about three days. This is not a pharmacological effect, like if you take a pain medicine or if you take … For example, if you have anesthesia, you immediately go to sleep, or if you take an IV shot of morphine, you immediately feel the effects. Because this involves growth of stem cells, then it takes time for that to grow. The beginnings of those effects from the actual growth usually start at about three weeks. Full effect is two to three months. In orthopedics, when using stem cells to help with tendon and bone, which grows much more slowly, full effect is six months to a year. Now, that doesn’t mean there won’t be effects the day of the procedure. Just like if you scrape your knee or if you have surgery and there’s a laceration that’s been sutured together, you can have symptoms of throbbing, you can have increased sensitivity, you can have decreased sensitivity, as with when you have a bruise it can feel boggy and decrease less sensitive. Then, when the healing comes, then things grow back.
That’s exactly what happens with the O-Shot. In the beginning, people can have decreased sensation that can happen, last from a few days to a few weeks. They can have increased sensation with hypersexuality and almost inability to get relief with multiple strong orgasms. This is more rare, but it happens. They could have increased libido. They can have urgency when they, like the urge to urinate. They can have frequency. They can have sexual arousal with urination, almost any sensation you can imagine, burning, itching, all sorts of things, but what’s usually observed by almost all women is nothing.Most women have a little spotting from the injection. There’s a lot of blood flow down there so they have some spotting and may wear a pantyliner for the day. Just like if you had a shot, you might need a band-aid to keep it from bleeding a few drops on your clothing. In the same way, there might be a few drops of blood. That’s about it. Most women, therefore, experience almost nothing for the first three weeks.
Then, things start to kick in. If they had pain, it starts to decrease and we’ll get into more specifics of what happens during that time when we get to discussing each problem that is treated with the O-Shot, but most of the effects, the beneficial effects start to happen at three weeks and the symptoms that might be more a nuisance, like decreased sensation or hypersexuality, start to go away by that time.
Let’s talk about the various problems that are treated with the O-Shot and how each might respond. Let’s start with decreased libido. Decreased libido can be from so many things. It can be emotional, it can be endocrine or from hormones. It can be because of a relationship problem with a partner. It can be past history, say, if the person was abused or something of that nature. Libido involves a lot of things. It can also be a positive or a negative spiral. For example, if a woman starts to have sex and then she has pain, then she starts to associate sex with pain and then she develops decreased sex drive or libido. If she has a good experience, then she starts to associate sex with something wonderful and so her sex drive may go up.
It is very true that there’s a very complicated system involving orgasm. The orgasm system is not the same as the reproductive system. A woman could have pregnancy without any sexual arousal at all, but it’s because there’s this complicated system, it doesn’t mean … Let me say that a different way. Anything in that system can affect it negative or positively. For example, we could give you the O-Shot, and you could have the healthiest vagina and clitoris on the planet, but if you’re emotionally bothered by a really poor relationship or emotional trauma from when you were a child, then the O-Shot is not going to make you have an amazing sex life. If you have an extremely low testosterone level where it seems impossible to have a libido, could be the same thing.
On the other hand, you could have the most amazing relationship and perfectly balanced hormones, but if you have genitalia that are scarred and causing you pain or with lichen sclerosus or decreased sensation from nerve damage from riding a bicycle or decreased blood flow for whatever problem, diabetes, all the things that could affect the genitalia, then all the emotions in the world may not be sufficient to make things as good as they could be, so we do not claim that the O-Shot fixes everybody’s sexual problems, but we do claim that healthy genitalia and the tissue of the genitalia is extremely important as part of the sexual or the orgasm system.
Back to libido. We have seen an extremely beneficial effect from the O-Shot, but all of those other things should be considered, endocrine relationship and emotional, especially testosterone levels should be … The free testosterone levels should be in the upper level, normal for the woman, and she should have her prolactin level checked to make sure it’s not too high.
What if the woman’s trying to have an orgasm and she’s never had an orgasm in her life? This is a very difficult problem and a very frustrating problem and affects about 10% of women. This is one of the less effective problems that the O-Shot helps, although we do have amazing results when it works. Women who’ve gone for many years and never had an orgasm in their life then start to have orgasm. We think what happens is that some women have less sensitivity in the area, and the O-Shot helps bring new blood flow and new nerve tissue to the area, allowing them to have a vaginal or clitoral orgasm, but, again, this one is more difficult because the problem can be so multifactorial. It’s like saying shortness of breath, if I give you bronchodilators, which would help someone with asthma for shortness of breath, but the reason you’re short of breath is you have carbon monoxide poisoning or you’re profoundly anemic and don’t have enough red cells to carry your oxygen, then the bronchodilators are not going to help, but it does not mean bronchodilators will not help the person who has bronchospasm from asthma, or maybe someone might have anemia or bronchospasm.
In the same way, our O-Shot does not make everyone well, say, for example, in the woman where everything is perfect with the labia and vagina and clitoris, but she’s suffering from extreme problems emotionally because of abuse, the O-Shot may not help her.
On the other hand, it could be that the abuse was physical, as I have seen in the past, and the woman has scarring from extreme physical abuse, and then the culmination of the O-Shot, which helped the pain from the scarring so that she’s now able to feel good and function again, gave her the confidence and to go out and seek a new relationship, so the physical helped the emotional healing. Listen to that again. A woman abused in the genitalia, scarring, extreme dyspareunia or pain with sexual intercourse, you could give her therapy all day long, every day, which she had for six, almost seven years before I treated her, but without effect, still leaving alone, and then after my O-Shot, the pain improved, her genitalia functioned more normally, she was able to have an orgasm more easily, sought a relationship. Her whole life was changed.
Again, with decreased libido, with decreased orgasm, it can be helpful, but it’s not total story.
We estimate, from our surveys, that if the woman has never had an orgasm in her life and everything else has been optimized as much as possible, the O-Shot is going to help her have an orgasm for the first time in her life in 30-40% of the time. If the woman has had an orgasms and continues to have orgasms, but they’re not as potent or as strong or as satisfying as they once were, this is a different matter. In this case, our O-Shot seems to help around 80% of the time.
Here again, the full effect appears to be around 8-12 weeks, so if you’re not feeling much at two weeks, it’s really too soon for the new nerve or the new blood flow or the new collagen to have even grown, so it does not mean that you will not have a satisfying result. Also, the procedure seems to be cumulative, just like it is with hair growth and treating the scar tissue in the face, which has been shown to help with acne scarring. Then, in those cases, the treatment is usually two to three treatments, about 6-12 weeks apart. Again, with our procedures, it also seems to be cumulative with the O-Shot for the various causes.
I recommend that you give the procedure at least eight weeks before you have it repeated, maybe even twelve depending on the severity and the strain on the relationship, etc., that might make you want to go sooner.
Here, it’s worth mentioning the various devices that are used in concert with the O-Shot. If you have radiofrequency or laser or electromagnetic therapy used along with your O-Shot, I recommend that you have those procedures done first with the O-Shot following. It can be done immediately following on the same day, but it should be the energy first and then the O-Shot. The growth factors are small amino acid peptide chains, so just like insulin, the amino acids are strung together in a way that act like a code that talk to the cell tissue. Growth hormone is another one. These amino acid chains, if they’re heated up, it denatures the protein, just like when you fry an egg, it changes the protein, and so they no longer code for the message. Therefore, if you gave an O-Shot on the same day, immediately after the O-Shot, if you did a laser treatment or radiofrequency, then you would undo what you had just accomplished with the laser or the radiofrequency.
The purpose of the laser or the radiofrequency is to incite damage that which then stimulates growth factors. We are injecting growth factors when we do the O-Shot, so it would enhance the effects of the laser or the radiofrequency, but if you do the O-Shot first, then you do the laser or the radiofrequency, you’re going to fry the growth factors that you just injected and, therefore, denature them so that they don’t work so well.
In the same way, if you do electromagnetic treatments to strengthen the pelvic floor, it’s been shown that PRP can help recover muscle, as well. As a matter of fact, for a while, it was banned by the Olympic committee, although they don’t ban it any longer, because PRP helps athletes recover. PRP’s now commonly used by athletes of many different forms, Olympic athletes, football players, even very expensive racehorses. Having muscle stimulation with electromagnetic therapy and then using platelet-rich plasma in the area can be a dramatic, like a pro-football, Olympic treatment for the pelvic floor.
Let’s talk about some of the other problems. Chronic interstitial cystitis, we are not sure why platelet-rich plasma helps, but it seems to help in a large percentage of the time, over half the time. It helps dramatically in women who have suffered for many years. We think this is because it both down regulates the autoimmune response and decreases inflammation with healing. In the short run, there can be an increase in inflammation. That’s part of the healing process, but in the long run, it gets much better.
We have women, as I said, have suffered for many years, and we’re not sure why. The whole idea of chronic interstitial cystitis is a difficult and painful problem. The O-Shot can be done in the normal manner. It doesn’t have to be injected into the bladder. It’s done in a normal manner around the paraurethral space, but we’re using a volume enough that is going to coat the bladder and the urethra.
In women who have chronic mesh pain, we also see amazing results, again, because we think it’s healing and decreasing some of the chronic inflammatory process that can go on with mesh. Some autopsy studies have shown that mesh wraps around the pudendal nerve, so if your doctor treats you for chronic mesh pain, you’ll do the procedure in the same way, but there also may be some injections around the distribution of pudendal nerve.
With mesh pain, it doesn’t usually go completely away, but we see a wonderful attenuation of that pain from say 10 to 2 or 8 down to 2 or 1, almost immediately, with full effect again being around two to three months out, but for some reason, platelet-rich plasma has an immediate attenuation in many women in this instance.
For lichen sclerosus, the usual protocol is that you’re injected, and then whatever places are still itching or look sclerotic or cracking, bleeding, etc., can be retreated at six weeks out, and then, oftentimes, the women has no symptoms, even without steroids for up to a year afterwards.
Lichen planus has a similar effect. This can be a painful procedure. It’s more painful than the others. With a regular O-Shot, some topical numbing cream and ice, a little local lidocaine block seems to be all that’s required for most women, but lichen sclerosus, either oral agent or some nitrous may be necessary to help attenuate some of the pain during the procedure.
When treating women who suffer with pain, as dyspareunia from various causes, the symptoms will vary depending on the cause. For example, if a woman has pelvic floor tenderness, she can put her finger or the physician can put his or her finger on the pelvic floor, and we produce the pain. That’s often treated with [inaudible 00:21:38] injection. We have found treating with platelet-rich plasma can lead to a better result, and the good thing about platelet-rich plasma, both in pelvic floor pain and with lichen sclerosus, is we’re doing something that enhances the immune system versus cortisone, which decreases the immune system. We do not know what long-term use of low-dose steroids do to the risk for various viral causes of cancer. In theory, it might make a woman more susceptible, although we don’t know that. However, platelet-rich plasma enhances the immune system and we would hope, my hope, decrease her chances of the viral illnesses that might cause cancer to wreak their havoc.
Also, a woman with lichen sclerosus has a 10% chance of squamous cell carcinoma, and we are hoping that the true antiinflammatory effects of lichen sclerosus as it attenuates, or of platelet-rich plasma in lichen sclerosus as it attenuates the autoimmune response might help decrease. We have to do the studies to find out, but we think it could help decrease the incidence of squamous cell carcinoma in lichen sclerosus.
Back to dyspareunia, if the woman has an episiotomy that causes pain, which they don’t always do, if she has an episiotomy scar that’s bleeding and cracking and causing pain, the O-Shot is absolutely the bomb, works amazingly well in this condition.
If she has really thin tissue in that area, she may need to be injected more than once, maybe two or three times with 8-12 weeks between treatments, but amazing, amazing results here.
If she’s got pain from fibroids, she needs surgery. If she has pain from big ovarian cysts, that’s not something the O-Shot’s going to help.
Before the O-Shot is used for pain, there should be understanding of what’s causing the pain, although not all pain is completely well understood and, oftentimes, the woman is left with an unsatisfying diagnosis, but if there is a surgical cause for the pain, then the O-Shot is not the treatment. If she needs a hysterectomy, she needs a hysterectomy, or if she needs treatment for ovarian cysts, that should be done, not an O-Shot.
If a woman has pain because of a small introitus, the usual treatment is gradually increasing dilators. In this case, you would do the same, only add to that treatment, an O-Shot prior to the dilator use.
The wonderful thing about platelet-rich plasma, again, after over 9,000 papers published in PubMed, there’s never been an incidence of a serious side effect, as in a serous infection, never been a documented causing cancer, there’s never been a documentation of any serious granuloma, none of those things, unlike, say, for example, midurethral slings, which we know can interfere with the nerves of sexual pleasure. Midurethral slings are a good procedure when they work, and I’m not saying they shouldn’t be done, but it’s perfectly reasonable to try a nonsurgical option first, especially when we know that the symptoms and side effects when a sling goes wrong are much more severe than what’s ever been documented with platelet-rich plasma.
For stress incontinence, what can happen is that when that platelet-rich plasma turns to a fibrin matrix, sometimes, the woman can experience relief of her stress incontinence that day, but then the matrix gets replaced by normal tissue, and it could be that her incontinence starts to come back over the next week or two, and then, as the new tissue grows from three weeks to three months, it improves again.If it’s not completely relieved, she should consider having it repeated at eight to twelve weeks. There does seem to be some synergy with stress incontinence if she has radiofrequency or laser treatment or a electromagnetic pelvic floor treatment prior to the O-Shot.
Urge incontinence surprisingly also works very well with the O-Shot. That most likely is from the nerves growing, and there are multiple papers showing that PRP causes new nerves to generate, so this can happen, but nerves grow very slowly, so if you’re treated mixed incontinence, where’s there a component of urge incontinence, then plan on at least eight to twelve weeks before you see the effects of it, and you most likely will want to have a repeat treatment done and then decide after the second treatment whether it was effective or not.
Thank you for listening. I hope this helps clear up some of the general ideas relating to this procedure. We have over 1,000 physicians in over 50 countries we’ve done. We’re approaching now 100,000 procedures. This is an extremely revolutionary procedure, and I’m honored to be cooperating with all the amazing providers in our group, and I encourage you to see the provider that took care of you, whether your results was wonderful or if it was not so wonderful, so that we can better take care of you and better learn about how to choose the best candidate for the procedure and how to develop the procedure so that it might work better.
I’m honored to speak with you, and I hope that you’ll let me know how you do. Remember, our survey is extremely important, and sharing your data could help us plan future research and help many thousands of women in the future. Thank you.
Needed information about how to make things better…
Maureen McGrath: It’s been said if you never want to have sex again, get married. Sex is one of the most contentious issues in marriage today, second only to finances. There are many married couples that have not had sex for months, even years, and that’s okay as long as they’re okay with it and happily married. The problem arises when one person in the relationship wants sex and the other doesn’t. According to a national newspaper survey of approximately 10,000 respondents, mostly married men, 75% were satisfied in their relationship but more than 50% were dissatisfied with their sex lives. We’re having sex, don’t get me wrong, we’re just having sex at the wrong time and with the wrong people, I’ll get to that later.
We’re having sex before we get married, 10 years on average, so we are effectively in a long term relationship and potentially quite sexually bored before we even mess up the marital bed. That has its consequences. Most brides today do not have sex on their wedding nights, and 50% of men would not have married their spouse had they known their marriage was going to be sexless. So, everybody wants to know, just how much sex are married people having, whether they are in heterosexual relationships or same sex unions, you all want to know what’s going on at the Jones’? Well not much.
Only about 7% of married couples set the sheets ablaze. Most married couples have sex a little more than once a week for the first decade of their marriage, it decreases after that. So they have sex about 58 times a year, and 20% of marriages meet the criteria as a sexless marriage. That, defined by the experts, is sex less than 10 times a year. So why aren’t we having sex in our marriages? Well, there’s a little known chemical in the brain conveniently called PEA, or PEA. It’s responsible for the elation, the excitement and the euphoria that you feel when you meet somebody that you are sexually interested in.
It’s a fantastic feeling, this chemical is scourging through your blood vessels, you are so happy, that’s how powerful this little chemical is. What happens after two years, that chemical diminishes as does sexual frequency. That’s just about the time you might get married or might have conflict in your relationship and that is why communication is key to great sex. There’s another reason we’re not having sex in our relationships, that has to do with the sex education that we provide. I’d like to share a story about myself, when I was a teenager my mother came racing into my bedroom and she said, “Maureen, please tell me you have not allowed a boy to french kiss you!” She was feeling terrible that this sex education came a bit late, I was feeling horrifically guilty as an Irish catholic girl that I’d french kissed a number of boys by that stage.
We teach girls and women that sex is dirty and sex is bad or it’s overrated. We say, you’re just going to get a sexually transmitted infection anyway, or you might get pregnant! This whole fear based thing frightens women from enjoying sex and we never talk about pleasure with girls and women, or orgasm. In fact, some women say orgasm is not important and that the journey is just as good as the destination. I disagree. Of course. I’m the one who french kissed all the boys as an Irish catholic girl. It’s like getting on a train with your lover, and you are going to the most pleasurable place on the planet. You are so excited, you’re getting lubed up with all the free drinks they’re giving you, this is amazing. Just before you reach your destination, he gets off and you don’t. You get my point.
Now, the sex education we have for boys and men, that’s entirely different. It’s a global program, it’s free, it’s accessible to everybody and it’s known as internet pornography. Fantastic. It does nothing to teach men and boys about intimacy which is really important to men and boys, or how to make love to anybody, also we have a paucity of information about sexual health for our LGBTQI community and we need to add to that. Now marriage can rapidly go from holy matrimony to holy hell with the finances, the kids, the houses, the illness. You may have signed up for sickness and health but that was long before you’d ever witnessed a man cold, and how about that richer or poorer thing? Ladies we’re going to have to start going for richer.
Most women today are working inside and outside of the home. We’re doing the lion share of the housework because according to research, men don’t feel they’re that good at it. We’re bridging the gap between growing children and aging parents. We’re exhausted doing it all and never doing it, and when we are doing it, we’re checking our smartphones. 10% of people check their smartphones during sex. 35%immediately afterward. We are connected to the internet. We are connected to the internet and disconnected from our would be lovers. Maybe this is the reason that the most common sex position for married couples is doggy style. No, no, no. It’s not what you’re thinking. Get your minds out of the gutter.
This is the one where he’s on all fours and begs and she plays dead. I have a clinical practice where I see patients that have sexual disfunction and there are two questions that I ask everybody. The first one is, are you sexually active? That’s obvious. When I ask women they never say yes or no. Well, they never say yes. But they never say yes or no. They say; sometimes, sort of, I’m not sure, he is or they say “I’m married.” I say well that means no to me. They say yes you’re right, it is no. Most men complain that women never initiate sex. The reason for this is because once again the sex education we provide to women, women falsely believe that female sexual interest, desire, precedes sexual activity when in actuality, it is sexual activity that prompts sexual interest and desire. Sexual arousal emerges as a result of sexual activity.
So, you guys I know, intimacy is important to you. The most important question that reflects this that I receive from you is, “How much masturbation is too much masturbation?” So I just say as long as you can go to work, you should be fine. Then I realize, that that’s perhaps all that you’re doing at work. So I know intimacy is important, you want to come home and you want to make love to your wife if you’re in a heterosexual relationship, so after a long and quite possibly very hard day, you come home to a bit of chaos perhaps, you’ve just got sex on the mind and she says, “Did you remember the milk?” You’re like darn, the milk! I forgot the milk. Don’t beat yourselves up about it, if not for the milk we have Facebook, hormones, I’m feeling a little tired tonight, my stomachs sticking out I’m feeling kind of fat, can’t do it tonight, didn’t we have sex last month? You’re like, that was actually last year. You don’t get it. Literally, you don’t get it.
You’re like she’s amazing, she works in and outside of the home, she does a great job with the kids, she volunteers, she even has time for girls nights out. So, I brought a friend home after one such girls night out. As we approached her house, drove up she looked up to her bedroom window, saw that the lights were on and she said, “Donny’s waiting up for me, do me a favor, drive around the block a few times until the light goes out” I said listen, “You get in there and make love to your husband before somebody else does” Because that is one thing that will increase a woman’s sexual desire, when someone else wants her man. Still unconvinced she said, “I decided to extol the health and beauty benefits that sex has for a woman, a youthful glow, better sleep, wrinkle free skin. Keep driving” She said.
There is a device that will increase anybody’s sexual desire and that happens to be the Mercedes Benz 4MATIC convertible SL and it comes in 64 colors. If that doesn’t do it, the desire to have a baby will rev up any woman’s sex drive. The problem is, having that baby is likely to kill it along with any marital eroticism a couple may have had. A lot of people believe that motherhood and being sexual is incongruousness. John, John followed me on LinkedIn for two years before he mustered up the courage to make an appointment about his sexless marriage. He’d been married for seven years and they had never consummated the relationship. Their parents were pressuring them to have parents because they wanted grandchildren. When they came into my clinical practice, the second question that I ask everybody that enters my clinical practice most unfortunately is, “Have you ever experienced sexual abuse or unwanted sexual advances as a child?”
This was the first time this gentle man had learned that his wife had experienced sexual abuse as a six year old at the hands of her best friend’s father. She thought sex was dirty, she hated sex, we need a worldwide moratorium on ending sexual violence on our children, boys and girls, because it happens to both. Healing from sexual abuse takes a lifetime. Ella had lived a lifetime. A widow, she said she wasn’t sexually active but she hoped to be. I thought, fantastic! Somebody is going to have sex here, but she said, “The problem Maureen is that these old guys can’t get it up anymore” I said well Ella, you might have to go for a younger guy. She said, “What’s younger when you’re 84? 70?” Yes some of you are saying.
The hard truth is that men in their 30s and 40s may experience erectile dysfunction. Ella is going to have to go for a millennial. So you’re all probably thinking, “What’s the big deal, why treat my erectile dysfunction?” Well I liken the penis to a plane, if a pilot can’t get the plane up in the air, and keep the plane in the air for the entire trip, there’s probably a problem with the engine. So if you can’t get your penis up and keep it up for the entire sexual experience, there’s likely a problem with your engine. That’s your heart. Erectile dysfunction is the canary in the coal mine and it may signify cardiovascular disease. It may also indicate diabetes. These two medical conditions in addition to low testosterone, stress, substance use and abuse, excessive alcohol consumption, unresolved conflict, financial issues, all of those may contribute to low sexual desire and you may end up in a sexless marriage.
George presented to my clinical practice at age 40, he decided to settle down. He was marrying a beautiful and accomplished woman in a few months. There’s only one problem, George was gay. George could not bear to tell his family that he was gay because he felt it would have shamed the entire family. I said, “George, you’re going to end up in a sexless marriage!” He said, “Tell me something I don’t know!” George said to me his plan was this, “Well, when my parents die I’m then going to divorce this woman and I’m going to marry the man that I love” And I said, “George, you are not thinking straight.” Sex is the barometer of the state of affairs in a marriage. People who live in sexless marriages report feeling frustrated, unloved, undesirable, unattractive and the worst of all, lonely.
Loneliness has been shown to increase vascular resistance and elevate blood pressure and lead to an early death. You’re more likely to die from loneliness than you are from obesity or excessive alcohol consumption. When I educate women and I say, “If you’re not having sex with your husband, someone else may” They get upset and they say that I’m blaming women for men’s bad behavior when in actuality I’m doing a community service. You see, men in sexless marriages cheat to remain in that marriage in general. Women cheat to leave a sexless marriage. Women cheat too, nobody ever thinks we do but we’re just sneakier about it, we just don’t get caught or socialize very differently, this is one thing we have on you guys. Women cheat with other men and women cheat with other women.
Technology has made cheating accessible for everybody, from the politician to the stay at home parent, that quick swipe right can lead to an online passionate love affair. From texting to sexting to secret phone conversations. The more two people communicate online, the more likely an in-person encounter will occur, but you can always blame your genes. The gene DN4N has been isolated in cheaters and the sexless marriage, just the environment to turn on that gene. It’s based on a system of pleasure and reward. The stakes are high, the rewards substantial. It is the perfect cocktail to turn that love drug back on, PEA and the cycle begins again. Historically, marriage was not based on mutual love but rather it was an institution to acquire of all things in laws, property and physical labor. At the turn of the 20th century, in America, egalitarian ideals and the emerging Hollywood movie industry burdened marriages with promising romantic love forever.
Now we’re living forever, fantastic, congratulations, you get to have sex with the same person for the rest of your life. The second most common question that I hear from patients is, “When does sex end?” Well a 44 year old asked me, he said, ” When does sex end Maureen, 65?” I answered him this way, a 22 year old asked me, “When does sex end Maureen, 35?” Everybody’s older until you get there. I’m here to tell you that sex never ends. If you’re healthy, you can have a great sex life well into your 80s and 90s. Sex is good for you, sex is healthy, yet sex is shrouded in shame. In the ancient aristocracies, the wealthy men had courtesans for pleasure and concubines for quick sex. The way we’re going, computers will be our concubines, internet pornography our mistress of the day. Technology is fast replacing human connection at high speed.
So how do you rev up the sexless marriage?
Sex is about blood flow, sexercise. Every day you want to have a daily workout. It increases your agility, your stamina, women will experience more sexual sensation when blood is flowing to the genitalia. It also helps to treat erectile dysfunction.
Pay more attention to your spouse than you do your smartphone.
Spend more time in your bedrooms than you do your boardrooms or your bedrooms are going to become bored rooms.
Deal with your marital issues.
Go to sleep in the same bed at the same time and don’t bring anything or anyone into your marriage except for a great sex toy and a darn good sex therapist.
You must establish guidelines that govern those moments when you are struck by someone’s attractiveness outside of your marriage, but don’t think for a second that you have to have sex with the same person for the rest of your life. That’s not what I mean. In your mind, that is. Fantasy is key. Your brain is your largest sex organ, and one more thing.
I would like to leave you all off with a bang. Settle all marital arguments in the bedroom, naked.
Needed information about how to make things better…
Maureen McGrath: It’s been said if you never want to have sex again, get married. Sex is one of the most contentious issues in marriage today, second only to finances. There are many married couples that have not had sex for months, even years, and that’s okay as long as they’re okay with it and happily married. The problem arises when one person in the relationship wants sex and the other doesn’t. According to a national newspaper survey of approximately 10,000 respondents, mostly married men, 75% were satisfied in their relationship but more than 50% were dissatisfied with their sex lives. We’re having sex, don’t get me wrong, we’re just having sex at the wrong time and with the wrong people, I’ll get to that later.
We’re having sex before we get married, 10 years on average, so we are effectively in a long term relationship and potentially quite sexually bored before we even mess up the marital bed. That has its consequences. Most brides today do not have sex on their wedding nights, and 50% of men would not have married their spouse had they known their marriage was going to be sexless. So, everybody wants to know, just how much sex are married people having, whether they are in heterosexual relationships or same sex unions, you all want to know what’s going on at the Jones’? Well not much.
Only about 7% of married couples set the sheets ablaze. Most married couples have sex a little more than once a week for the first decade of their marriage, it decreases after that. So they have sex about 58 times a year, and 20% of marriages meet the criteria as a sexless marriage. That, defined by the experts, is sex less than 10 times a year. So why aren’t we having sex in our marriages? Well, there’s a little known chemical in the brain conveniently called PEA, or PEA. It’s responsible for the elation, the excitement and the euphoria that you feel when you meet somebody that you are sexually interested in.
It’s a fantastic feeling, this chemical is scourging through your blood vessels, you are so happy, that’s how powerful this little chemical is. What happens after two years, that chemical diminishes as does sexual frequency. That’s just about the time you might get married or might have conflict in your relationship and that is why communication is key to great sex. There’s another reason we’re not having sex in our relationships, that has to do with the sex education that we provide. I’d like to share a story about myself, when I was a teenager my mother came racing into my bedroom and she said, “Maureen, please tell me you have not allowed a boy to french kiss you!” She was feeling terrible that this sex education came a bit late, I was feeling horrifically guilty as an Irish catholic girl that I’d french kissed a number of boys by that stage.
We teach girls and women that sex is dirty and sex is bad or it’s overrated. We say, you’re just going to get a sexually transmitted infection anyway, or you might get pregnant! This whole fear based thing frightens women from enjoying sex and we never talk about pleasure with girls and women, or orgasm. In fact, some women say orgasm is not important and that the journey is just as good as the destination. I disagree. Of course. I’m the one who french kissed all the boys as an Irish catholic girl. It’s like getting on a train with your lover, and you are going to the most pleasurable place on the planet. You are so excited, you’re getting lubed up with all the free drinks they’re giving you, this is amazing. Just before you reach your destination, he gets off and you don’t. You get my point.
Now, the sex education we have for boys and men, that’s entirely different. It’s a global program, it’s free, it’s accessible to everybody and it’s known as internet pornography. Fantastic. It does nothing to teach men and boys about intimacy which is really important to men and boys, or how to make love to anybody, also we have a paucity of information about sexual health for our LGBTQI community and we need to add to that. Now marriage can rapidly go from holy matrimony to holy hell with the finances, the kids, the houses, the illness. You may have signed up for sickness and health but that was long before you’d ever witnessed a man cold, and how about that richer or poorer thing? Ladies we’re going to have to start going for richer.
Most women today are working inside and outside of the home. We’re doing the lion share of the housework because according to research, men don’t feel they’re that good at it. We’re bridging the gap between growing children and aging parents. We’re exhausted doing it all and never doing it, and when we are doing it, we’re checking our smartphones. 10% of people check their smartphones during sex. 35% immediately afterward. We are connected to the internet. We are connected to the internet and disconnected from our would be lovers. Maybe this is the reason that the most common sex position for married couples is doggy style. No, no, no. It’s not what you’re thinking. Get your minds out of the gutter.
This is the one where he’s on all fours and begs and she plays dead. I have a clinical practice where I see patients that have sexual disfunction and there are two questions that I ask everybody. The first one is, are you sexually active? That’s obvious. When I ask women they never say yes or no. Well, they never say yes. But they never say yes or no. They say; sometimes, sort of, I’m not sure, he is or they say “I’m married.” I say well that means no to me. They say yes you’re right, it is no. Most men complain that women never initiate sex. The reason for this is because once again the sex education we provide to women, women falsely believe that female sexual interest, desire, precedes sexual activity when in actuality, it is sexual activity that prompts sexual interest and desire. Sexual arousal emerges as a result of sexual activity.
So, you guys I know, intimacy is important to you. The most important question that reflects this that I receive from you is, “How much masturbation is too much masturbation?” So I just say as long as you can go to work, you should be fine. Then I realize, that that’s perhaps all that you’re doing at work. So I know intimacy is important, you want to come home and you want to make love to your wife if you’re in a heterosexual relationship, so after a long and quite possibly very hard day, you come home to a bit of chaos perhaps, you’ve just got sex on the mind and she says, “Did you remember the milk?” You’re like darn, the milk! I forgot the milk. Don’t beat yourselves up about it, if not for the milk we have Facebook, hormones, I’m feeling a little tired tonight, my stomachs sticking out I’m feeling kind of fat, can’t do it tonight, didn’t we have sex last month? You’re like, that was actually last year. You don’t get it. Literally, you don’t get it.
You’re like she’s amazing, she works in and outside of the home, she does a great job with the kids, she volunteers, she even has time for girls nights out. So, I brought a friend home after one such girls night out. As we approached her house, drove up she looked up to her bedroom window, saw that the lights were on and she said, “Donny’s waiting up for me, do me a favor, drive around the block a few times until the light goes out” I said listen, “You get in there and make love to your husband before somebody else does” Because that is one thing that will increase a woman’s sexual desire, when someone else wants her man. Still unconvinced she said, “I decided to extol the health and beauty benefits that sex has for a woman, a youthful glow, better sleep, wrinkle free skin. Keep driving” She said.
There is a device that will increase anybody’s sexual desire and that happens to be the Mercedes Benz 4MATIC convertible SL and it comes in 64 colors. If that doesn’t do it, the desire to have a baby will rev up any woman’s sex drive. The problem is, having that baby is likely to kill it along with any marital eroticism a couple may have had. A lot of people believe that motherhood and being sexual is incongruousness. John, John followed me on LinkedIn for two years before he mustered up the courage to make an appointment about his sexless marriage. He’d been married for seven years and they had never consummated the relationship. Their parents were pressuring them to have parents because they wanted grandchildren. When they came into my clinical practice, the second question that I ask everybody that enters my clinical practice most unfortunately is, “Have you ever experienced sexual abuse or unwanted sexual advances as a child?”
This was the first time this gentle man had learned that his wife had experienced sexual abuse as a six year old at the hands of her best friend’s father. She thought sex was dirty, she hated sex, we need a worldwide moratorium on ending sexual violence on our children, boys and girls, because it happens to both. Healing from sexual abuse takes a lifetime. Ella had lived a lifetime. A widow, she said she wasn’t sexually active but she hoped to be. I thought, fantastic! Somebody is going to have sex here, but she said, “The problem Maureen is that these old guys can’t get it up anymore” I said well Ella, you might have to go for a younger guy. She said, “What’s younger when you’re 84? 70?” Yes some of you are saying.
The hard truth is that men in their 30s and 40s may experience erectile dysfunction. Ella is going to have to go for a millennial. So you’re all probably thinking, “What’s the big deal, why treat my erectile dysfunction?” Well I liken the penis to a plane, if a pilot can’t get the plane up in the air, and keep the plane in the air for the entire trip, there’s probably a problem with the engine. So if you can’t get your penis up and keep it up for the entire sexual experience, there’s likely a problem with your engine. That’s your heart. Erectile dysfunction is the canary in the coal mine and it may signify cardiovascular disease. It may also indicate diabetes. These two medical conditions in addition to low testosterone, stress, substance use and abuse, excessive alcohol consumption, unresolved conflict, financial issues, all of those may contribute to low sexual desire and you may end up in a sexless marriage.
George presented to my clinical practice at age 40, he decided to settle down. He was marrying a beautiful and accomplished woman in a few months. There’s only one problem, George was gay. George could not bear to tell his family that he was gay because he felt it would have shamed the entire family. I said, “George, you’re going to end up in a sexless marriage!” He said, “Tell me something I don’t know!” George said to me his plan was this, “Well, when my parents die I’m then going to divorce this woman and I’m going to marry the man that I love” And I said, “George, you are not thinking straight.” Sex is the barometer of the state of affairs in a marriage. People who live in sexless marriages report feeling frustrated, unloved, undesirable, unattractive and the worst of all, lonely.
Loneliness has been shown to increase vascular resistance and elevate blood pressure and lead to an early death. You’re more likely to die from loneliness than you are from obesity or excessive alcohol consumption. When I educate women and I say, “If you’re not having sex with your husband, someone else may” They get upset and they say that I’m blaming women for men’s bad behavior when in actuality I’m doing a community service. You see, men in sexless marriages cheat to remain in that marriage in general. Women cheat to leave a sexless marriage. Women cheat too, nobody ever thinks we do but we’re just sneakier about it, we just don’t get caught or socialize very differently, this is one thing we have on you guys. Women cheat with other men and women cheat with other women.
Technology has made cheating accessible for everybody, from the politician to the stay at home parent, that quick swipe right can lead to an online passionate love affair. From texting to sexting to secret phone conversations. The more two people communicate online, the more likely an in-person encounter will occur, but you can always blame your genes. The gene DN4N has been isolated in cheaters and the sexless marriage, just the environment to turn on that gene. It’s based on a system of pleasure and reward. The stakes are high, the rewards substantial. It is the perfect cocktail to turn that love drug back on, PEA and the cycle begins again. Historically, marriage was not based on mutual love but rather it was an institution to acquire of all things in laws, property and physical labor. At the turn of the 20th century, in America, egalitarian ideals and the emerging Hollywood movie industry burdened marriages with promising romantic love forever.
Now we’re living forever, fantastic, congratulations, you get to have sex with the same person for the rest of your life. The second most common question that I hear from patients is, “When does sex end?” Well a 44 year old asked me, he said, ” When does sex end Maureen, 65?” I answered him this way, a 22 year old asked me, “When does sex end Maureen, 35?” Everybody’s older until you get there. I’m here to tell you that sex never ends. If you’re healthy, you can have a great sex life well into your 80s and 90s. Sex is good for you, sex is healthy, yet sex is shrouded in shame. In the ancient aristocracies, the wealthy men had courtesans for pleasure and concubines for quick sex. The way we’re going, computers will be our concubines, internet pornography our mistress of the day. Technology is fast replacing human connection at high speed.
So how do you rev up the sexless marriage? Sex is about blood flow, sexercise. Every day you want to have a daily workout. It increases your agility, your stamina, women will experience more sexual sensation when blood is flowing to the genitalia. It also helps to treat erectile dysfunction. Also get help for any of the sexual dysfunctions you may have, vaginal dryness, it’s an issue that happens to women who are on the oral contraceptive pill, who are breastfeeding, perimenopausal, postmenopausal and there are treatments for you. Pay more attention to your spouse than you do your smartphone. Spend more time in your bedrooms than you do your boardrooms or your bedrooms are going to become bored rooms. Deal with your marital issues.
Go to sleep in the same bed at the same time and don’t bring anything or anyone into your marriage except for a great sex toy and a darn good sex therapist. You must establish guidelines that govern those moments when you are struck by someone’s attractiveness outside of your marriage, but don’t think for a second that you have to have sex with the same person for the rest of your life. That’s not what I mean. In your mind, that is. Fantasy is key. Your brain is your largest sex organ, and one more thing. I would like to leave you all off with a bang. Settle all marital arguments in the bedroom, naked.
1. Does the PRP always come from the patient’s own blood?
Always Always ALWAYS the PRP comes from the patient’s own blood. And the FDA approved kits are disposable, so we are always using a new kit to prepare the blood and then throw that kit away before we treat the next woman. Most of us even process the blood in the same room with the patient so that they can see that it’s always their blood. Hence, there is zero chance of them catching something from another person.
2. What year did the O-Shot originate and how many professionals have been trained to give it in the US?
Dr. Runels did the first O-Shot alone with his lover in early 2011 (after first treating many faces and treating his own penis (with the Priapus Shot® procedure) and the penis of other men—the anatomy and cell biology of the penis mirror the clitoris). Since then, over 1,000 physicians in the US alone representing most states (and other providers in over 50 countries) have been trained, and he’s trained faculty from 5 different medical schools in the US alone.
3. I’ve read about complications if PRP in general isn’t prepared correctly, but what are the potential side-effects related to the O-Shot?
2 Parts to this answer.
1. Serious side effects (infection, granuloma, scaring, death) do NOT happen (at least none reported after MILLIONS of PRP injections).
Anything can happen anytime. And no procedure is perfect (even antibiotics fail 1 in 5 times for those hospitalized with pneumonia). Also, the most simple of procedures can lead to complications. Patients can crash their car driving to the office…so just driving to the doctor’s office has a risk. But, if someone saw a life-threatening reaction to PRP—anywhere it may be injected other than the eye—it would be the first reported case.
Another important point…we are creating a “hematoma” of sorts by injecting blood into an area. This is not a drug, like morphine where the cells of the body start reacting differently, This procedure encourages healthy tissue growth.
During the first phase there can be side effects (good and bad) from the fluid injected and the resultant vasodilitation etc.
The actual benefits from the procedure happen with new cell growth which takes 3 to 12 WEEKS or more (in orthopedic procedures the full effects can be 6 to 12 MONTHS).
So, both side effects and benefits are likely to be temporary until the 12 week mark, then you have a better idea of the effects of the procedure. Even after that, there can be continued changed due to remodeling of the tissue prompted by the PRP.
Any benefits, problems, or side-effects seen in the first 3 weeks, are likely to be from the PRP injected —which all goes away! It’s the effects of the new cell growth that provide the lasting effects.
.
Of the over 9,000 research papers published on PubMed (click to see) about PRP, there has been no serious life-threatening side effects in any of those papers, which makes sense because you’re injecting the blood component that’s normally made to repair tissue. So, we are injecting what the body would normally make to recover from surgery. Regen alone (one of the suppliers of FDA-approved PRP prep kits) sells over one MILLION kits per year—so the number of procedures being done in general number in the millions.
2. We have seen a variety of less serious (nonlife threatening) side effects with the O-Shot® [Orgasm Shot®] procedure.
a. Women with recurrent vaginal herpes see the frequency and severity of recurrence go DOWN (they suffer less). The “side effect’ here is a GOOD effect. This decrease in outbreaks makes sense because PRP enhances the body’s immune system against foreign pathogens. The platelet activation is normally a part of the wound healing process, so it makes sense that there’s intelligence about the response (not a simple-minded growth of whatever’s there like if you throw fertilizer on your lawn). This goes along with the fact that those with acromegaly and abnormally high levels of growth hormone have 25% less cancer than the general population. There are healing effects in the growth factors that make the results good from normal tissue and detrimental to pathogens and abnormal tissue (hence the effect of helping scars go away by remodeling the tissue back to a more normal configuration click).
b. Some women see hyper-sexuality that can be very very intense requiring almost constant sexual activity and not relieved well by orgasm. This happens in less than 1% and has never persisted more than a few days.
c. We’ve seen 6 or so reported cases (in over 50,000 procedures) of decreased ability to have and orgasm. We think this is happening from the effects of the edema caused by the injection. PRP has been shown to heal nerve tissue (click to read), so the PRP should not be damaging to the sensation. Is there micro damage in these women from the needle? Possibly, but not likely since there are multiple small nerve fibers, not one main nerve in the area we inject. Could the decreased sensation in these six women be related to something else going on with the woman? For example, one woman said the procedure caused back pain, but on a closer interview, it turns out that she and her husband were having such vigorous sex after the shot from her improved libido that she had a muscle injury that got better with a few days rest. Another woman thought the procedure CAUSED urinary incontinence, but on a closer interview, she simply had ejaculation with orgasm for the first time. Still, for some reason, we’ve seen sensation go DOWN instead of up in 6 reported cases, In all cases except one, the sensation came back to normal after 3-12 weeks.
d. The development of ejaculation with some orgasms.
e. Urgency, and frequency of urination for a few days.
f. Pain during injection. Usually, we can keep the pain at or near zero, but sometimes, just like at the dentist, the anesthetic may not be perfect.
g. Spotting after the injection. It IS and injection in the vaginal opening—where there’s much blood flow—so we she may see a few spots of blood.
h. Sexual arousal with urination for a few days.
i. There can be a change in the relationship. When a woman’s libido goes up, if her partner is not healthy, there can become a mismatch in sexual libido. If she now wants to have sex more than her partner, that can cause some tension. Better sex does not always mean a more peaceful relationship, though with most couples it does help.
k. If the woman is being treated for sexual problems and suffers with urinary incontinence, she will often see the “side effect” of the urinary incontinence going away.
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Dr. Marco Pelosi III: Our next speaker is probably best described as the Michael Jordan of platelet rich plasma, Dr. Charles Runels from Alabama, that pioneered the O-Shot® [Orgasm Shot®], the Vampire [Face]lift®, the P-Shot® [Priapus Shot®], and he’s taken all the abuse and he’s given the world some very, very useful procedures for everyone. He’s going to talk about the studies he did and the studies done in platelet rich plasma in regards to sexual function. Dr. Runels, it’s a pleasure to have you here.
I’m going to go through a whirlwind look at research that’s been done where people have used PRP to help with sex. Much of the research has been done by the people in our group, and I’ve described many of them in this room who have done this research. It’s a for-profit organization, but we pay for research, we pay for education, we pay for marketing for our providers. Just to echo what you just heard, sex is much more than about just having fun. Rainer Maria Rilke said it’s just so correlated to the creative experience that it’s affecting how we do our work, how you do your presentation, and how – of course – relationships and families.
I want to echo that sentiment, and remind us that back in 1980, if you look in ‘Urology’ – this was ‘Urology’ 1980 – the most common cause for erectile dysfunction was thought to be 85% psychogenic. Here’s a quote from ‘Urology’ where urologists were encouraged to become counselors, because most of erectile dysfunction was thought to be psychogenic. Of course, I’m echoing the penis stuff because if you take a penis and shrink it and unzip it, that becomes a clitoris. I’m thinking most of the research will eventually apply to that. Certainly, our attitude is applying because we’re back in the … We’re not, I’m preaching to the choir, but many of our colleagues are back in the 1980’s and saying the main thing we have for sexuality for women is counseling.
My thinking that perhaps, as you guys do, some of the pathology that applies to the penis may apply to the clitoris, and maybe some of these women are suffering from actual genital histopathology, not just psychogenic problems. We have this one FDA approved drug now for female sexual dysfunction that’s a psych drug, flibanserin. It’s a useful drug, but obviously, we need much more and maybe we should think in terms of systems, like we do for the rest of the body.
Platelet Rich Plasma.
Obviously, this is not a new idea. This is from, this month, over 9,000 papers indexed in PubMed about platelet rich plasma. Our orthopedic colleagues, our dentist, our facial plastic surgeons have worked with this, and all we have to do is take their ideas and then hopefully people in this room will extend what I’m about to show you and just take those ideas and adapt them to the genital space. Here’s some of the growth factors we know about. There are many more. They have these effects. These are good things for the genitalia. Down-regulating autoimmune response, proliferation of fibroblasts, new angiogenesis, the adipocytes enlarge and multiply – think labia majora, collagen production, neurogenesis and maybe some glandular function.
There’s never, in all those 9,000 papers, I still cannot find one serious side effect. No granulomas, no serious infection. PRP is what your body makes to heal when you do your surgeries and help prevent infection. Obviously, there are always certain things that can happen, bruising and such, but if you have a serious life-threatening complication from PRP, you will have the first recorded in all of that 9,000 plus papers. That’s a nice thing.
We have commercially available methods for preparing it, within 5 or 10 minutes of the bedside, and the devices are FDA approved. So you guys don’t get confused, obviously the FDA does not approve your procedures. That’s a doctor business. They don’t approve blood that belongs to you, just like your spit and your saliva and your skin. They tried, at one time, to control eggs and the gynecologists said, “Hell no.” So they don’t control eggs and they don’t control blood, but you should use an FDA approved device if you do this [approved for preparation of PRP to go back into the body].
Autoimmune Disease
Here’s some of the ideas about down-regulating autoimmune response. We have split-scalp studies showing that PRP helps alopecia areata better than triamcinolone. More hair growth that comes in thicker. Here’s rat studies looking at rheumatoid arthritis. What do we have in the genital space? We have lichens sclerosus. We did some before and after pictures where you use stem cells mixed with PRP, and before and after pictures show improvement. Of course, that’s two variables because you have stem cells and you have the PRP.
We took the same idea and just used PRP. Andrew Goldstein worked with me on this, and we had two blinded dermatopathologists. The protocol was biopsy, PRP, wait six weeks later, another PRP injection, and then six weeks after that, another biopsy. Two blinded dermatopathologists out of George Washington University did not know the before or the after. We showed statistical improvement in both the histology and symptomatology. Here’s our histology. You can see obviously, that’s the same magnification and we’re showing decreased hyperkeratosis. That’s obviously healthier tissue. A layperson could tell that’s better. Of course if you look at the gross pictures, lady on the left as you guys know, she has pain wearing her blue jeans. The lady on the right is back to making love to her husband. They’ve invited me into their close Facebook groups and I saw a post a few months ago. Quote says, “I was sitting next to my husband, whom I love, last night. I was afraid to hold his hand because I was afraid he would become aroused and I’m bleeding and hurting today.” That’s what you guys are helping.
We published that in ‘Lower Genital Tract Disease’. We extended it because it worked. We published this past January in the journal of the American Academy of Dermatology. You have some science to go do this now.
One of our providers, Kathleen Posey, who’s a gynecologist out of New Orleans, took this idea and then she said, “Let’s do some dissection in the office”, and she presented this in Argentina, published it in the same journal ‘Lower Genital Tract Disease’. Here’s one of her patients, where you can introduce [inaudible 00:06:44]. It had been 12 years since she had had sexual intercourse, penis and vagina intercourse, with her loving husband … 12 years. She was being followed by a dermatologist on high dose clobetasol. Kathleen dissected it out in the office and then injected PRP … 8 weeks later, she’s having comfortable sex with her husband. She’s now 3 years out. She’s had to be treated with PRP, not repeat surgery … PRP now, 2 other times a year apart to maintain that result. She now has a series of 60 or so patients that she’s now going to publish with similar results, where she’s dissecting out – as you guys know how to do – treating the [inaudible 00:07:27], but then following that with PRP injections to help the healing and decease the autoimmune response.
That same doctor, Casabona, repeated his study with lichen sclerosus in men [BXO], and showed with just PRP alone … This study of 45 men with repeat treatments … It is cumulative, 2 to 10 treatments, the same thing. All of them stopped their steroids. None of them started back. Only one went on to have circumcision.
Peyronie’s
Peyronie’s disease, another autoimmune disease … This came out this month out of Wake Forest, where they took men and they followed their results with Peyronie’s disease. Not only did their Peyronie’s improve statistically, but they also improved their erectile dysfunction by 5 on that scale of 5 to 25 that the urologists use. For some reason, thankfully, they threw in one woman just for good measure, and showed that it helped her incontinence. They just tucked that in as an aftermath.
Ronald Virag, as you guys know as the legendary vascular surgeon who was first to present the idea of intracavernosal injections for erectile dysfunction, out of Paris. His big thing now is PRP for Peyronie’s. He just published a study where he showed that this is comparing PRP with Xiapex, which is a $50,000 series of injections, FDA approved version of collagenase. He showed that PRP works better with few side effects. There’s a risk of about 1 in 30, that actually go from a bent pencil to a fractured pencil and a limp noodle. You don’t see that with PRP. You see the side effect is the erectile function improves. He showed the same thing, actually, in his studies that erectile dysfunction improves by an average of about 7 on that 5 to 25 point scale.
Wound Healing/Scar Resolution
Let’s think about the [inaudible 00:09:29] literature. Look at this, there’s so much of this out there. This is looking at post-operative adhesions, lots of studies looking at scarring with microneedling and PRP. This is a split-face study comparing PRP with microneedling verus PRP … Excuse me, microneedling with saline or Vitamin C serum and split-faced studies in PRP wins. Dr. Sclafani did some studies in the cosmetic space looking at increased collagen production and fibroblast activity, and never a neoplasia documented. People worry about that. This is not indiscriminate blindness blind growth. You don’t worry about carcinogenesis when you do surgery and it’s the same PRP that’s causing healing. There’s actually some helpful immune processes that go on, that you could argue actually might help prevent cancer. I’m not going to make that argument but it might need to be made one day.
If you look further, here’s a wound healing study looking at reepithelialized exposed bone and tendon of the foot and ankle. When I took that and applied, this is a hypertrophic scar that was a year old from cortisone, and then using PRP and Juvederm or HA filler, this is a few days later, a month later, and that’s a year later. Now, take that and think, “How could I use that in the genitourinary space?” Doing that anecdotally, we have many of the members of our group are seeing help with episiotomy scars or dyspareunia, pelvic foreplay instead of injecting that pelvic floor tenderness with triamcinolone. Physiatrist for the past ten years has been using PRP, your sports medicine doctors. Now, when you palpate it, consider injecting with PRP instead. Dyspareunia from mesh and that unknown dyspareunia, we’re seeing this is where we need you guys to help extend the research. The science is there that it should help and it seems to be helping. Not 100%, but about 80% in people with dyspareunia.
Mesh Pain
Here is a look at a gentleman who did … He took the mesh out and then he patched the hole with a gel form of PRP and showed benefit. We’re finding anecdotally – no one’s done this study yet, here’s another one for you to pick up … I’m giving you low hanging fruit. We’re seeing anecdotally that if you inject in the distribution of the pudendal nerve, which seems to be inflamed in some women with mesh pain, that their pain will frequently go from 9 out of 10 down to 1 or 2 out of 10, without even taking the mesh out. Just another place where we need some research done.
Interstitial Cystitis
Here, we have rat studies looking at inflammation. Let’s think about this one. Here’s a rat study where they modeled cystitis and we are seeing in chronic interstitial cystitis without even infiltrating the bladder, just infiltrating in the periurethral space, some of our women are getting better. I’ve had two separate urologists call me and say, “Charles, I can’t believe it. I was doing this and expecting not this to happen. I have these patients now who have had chronic interstitial cystitis pain for years, and it’s gone.” Not 1005 but finding out who’s going to respond and who’s not and why, there’s a lot of variables that need to be thought about that you guys will hopefully do the research.
Penis Growth
Here’s a study that came out in the ‘Journal of Sexual Medicine’, where a guy took … the [inaudible 00:12:51] men who have an erection of 3 inches or less and then he treated them with PRP, combined with a pump, and showed that if you repeated it every time you did it, it grew by about 7 millimeters. I’ve always thought if I could give you a guarantee half an inch to an inch with anything, I’d get my picture on a postage stamp. I don’t have that yet, but I can tell you that we’re seeing about 60% of the time we do this procedure, men will see some sort of growth.
If you look at the neovascular space, there was a study out of Southern California that was published in the ‘Journal of Sexual Medicine’ where they transferred adipocyte stem cells to the penis of diabetic rats. They showed new endothelial cell growth and increased nitric oxide activity in the dorsal nerve. Would that be helpful in the clitoris? Probably, but the interesting thing is the adipocyte-derived stem cells were attacked and they died. The postulate was the improvement was from the growth factors.
Penile Rehabilitation and Erectile Dysfunction
I have seen what [inaudible 00:13:52] have seen in that when you inject this in the penis, erectile function goes up on the average of about 5 to 7 per injection. Think about nerve repair. We have rat studies modeling prostrate surgery, showing that the nerves improved with PRP and so we have, again, another clear place where we need studies if you add this now to the usual protocol for rehabilitating the penis post-prostate surgery … would you see benefit? We have seen that in some of our patients who are a year or two out who failed the rehabilitation part of that. Would that help your patients who have, say, numbness and decreased function from riding their bikes too much, or trauma? I don’t know, but it’s worth thinking about and publishing research about.
In thinking about where to put this, where we do our O-Shot, when we do PRP to the anterior vaginal wall, we’re putting it as distal from the bladder as possible. We found that it works better. We’re essentially making a liquid sling. Think infiltrating and getting ready to put in the mesh. That’s what we’re doing. Very simple, only we’re using a material that has never caused a granuloma ever. Doing that, frequently our patients will have their incontinence go away that day from the actual liquid and as it’s replaced with new tissue, it never recurs. Usually, you’ll have to repeat the procedure at a year or two out depending on the etiology. Sometimes it lasts longer.
The interesting idea is what might be happening with those [inaudible 00:15:21]. They become more active, and does that help with sexual function? The other place we put it is in the actual corpus cavernosum of the clitoris. We use [inaudible 00:15:29] ultrasound visualization and see it flow down into the body of the clitoris by the pubic ramus and the wave form goes to what you see in a flaccid penis to what you see in an erect penis.
Improved Orgasm & Libido in Women
That’s my time, almost done. Just 30 more seconds. Here’s a pilot study we did where we showed that in women with female sexual distress, that it dropped by an average of 10 and female sexual function went up by 5 when you do what I just showed you. Here’s a study that Dr. Neto, who may be here, published where he looked at incontinence and sexual function down in Brazil and showed that 94% of the people loved it. The question here is how would you combine it with your energy source? It works great in the face if you do laser and follow it with PRP … better results, faster healing. Is it going to … We need people to help us work out the algorithms. Not everybody has laxity, but when you have something, when do you use which treatment and when do you combine it with PRP? We need those answers, because I don’t have them yet. This is possible helps.
I am done. Thank you very much for having me. I put all these references at that website, if you want to go download them. Thank you. You guys have a wonderful conference.
Dr. Marco Pelosi III: Thank you Charles. Beautiful
