Year: 2025
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Lynkuet® Combined Second Therapy for a Powerful Synergy to Help Women Suffering from Breast Cancer
Hormone‑Free Relief for Hot Flashes & Improvement of Sex
I lost my sister to breast cancer.
I hate it.
One in 8 women will have to fight this horrific disease.
Today, I was happy to read that the FDA approved a new drug, Lynkuet®, to help women with hot flashes. The drug is made especially for women who have suffered from breast cancer or have a strong family history of breast cancer and do not want to take estrogen.
It works by affecting the midbrain, which controls your temperature and gets way out of whack without estrogen.
It does not affect the tissue of the vagina, so it does not help with the dryness and pain with intimacy that also comes without estrogen.
That’s why combining Lynkuet® with our O-Shot® procedure could be a wonderful combination: Lynkuet for the hot flashes, the O-Shot to help with intimacy.
The combination of the two could be a life-changer.
Remember: Women who cannot take estrogen may still benefit from progesterone and testosterone (both of which can downregulate estroge receptors). Still, that strategy can be troublesome for some women and should be discussed with your physician.
But, the combination of the O-Shot® with Lynkuet™ would be safe even for someone at high risk for breast cancer who wanted to take no hormones.
Here’s more detail (with references) about how the two might work together…
The O‑Shot® (PRP): Local, Regenerative Relief
The O‑Shot® is a very specific method of using your own platelet‑rich plasma (PRP) to regenerate and support healthy vaginal tissue. Growth factors in PRP encourage blood flow, elasticity, and natural lubrication — without adding hormones.
- In‑office procedure (~20 minutes) with local anesthetic
- No downtime; results build over weeks
- Designed to improve dryness, comfort, decrease urinary incontinence, and increase sexual pleasure
Lynkuet™ (elinzanetant): Non‑Hormonal Help for Hot Flashes
Lynkuet™ is an FDA‑approved, non‑hormonal oral therapy for vasomotor symptoms (hot flashes/night sweats). It blocks neurokinin‑1 and neurokinin‑3 receptors on KNDy neurons to calm the body’s thermostat.
Why both?
O‑Shot® works locally for vaginal moisture and comfort; Lynkuet™ works centrally for hot flashes — a complementary, hormone‑free approach.
Peer‑Reviewed Research You Can Read
- PRP vs. Estrogen for Postmenopausal VVA: PRP outperformed estrogen at 12 weeks on FSFI and VSQ in a 66‑patient study. Frontiers in Medicine, 2025
- Breast‑Cancer Survivors (often can’t use hormones): One‑time intravaginal PRP improved VHI, FSFI, and other GSM scores through 6 months; no serious AEs. Obstetrics & Gynecology, 2025
- Scoping Review (43 studies): PRP improved dryness, sexual function, and pain in gynecologic conditions; generally well tolerated. J Clin Med, 2025
- Lynkuet™ MoA & Approval: Dual NK‑1/NK‑3 antagonist for moderate‑to‑severe hot flashes/night sweats. Bayer press release, Oct 24, 2025
->Find a Certified O‑Shot® Provider<-
Is This Right for You?
If you prefer to avoid hormones — or can’t use them — speak with your physician or schedule a medical consult with a licensed O‑Shot® provider to review your history, medications, and goals, and to discuss whether LynkO might fit your care plan.
Educational only; not personal medical advice. Outcomes vary. Discuss risks, benefits, and alternatives with your clinician.
Charles Runels, MD
Cellular Medicine Association
Oshot.info | CellularMedicineAssociation.org
888‑920‑5311 -
You are not broken, You are unbalanced
Travis Woodley is a brilliant healer and concerned scholar. Pay attention to this book!
Charles Runels, MD
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Stress Urinary Incontinence in Teenage Women
Read the research referenced in the video<- Find the nearest O-Shot® Provider<-Some of the Research Supporting the Effectiveness of the O-Shot® Procedure for Treating Stress Urinary Incontinence
- Ashton, Leah, Hannah Nakatsuka, Colin M. Johnson, et al. “A Single Injection of Platelet-Rich Plasma Injection for the Treatment of Stress Urinary Incontinence in Females: A Randomized Placebo-Controlled Trial.” Urology 193 (November 2024): 63–68. https://doi.org/10.1016/j.urology.2024.06.047.
- Boztepe, Ozlem, and Hannah Warren. “Letter to Editor – A Single Injection of Platelet-Rich Plasma Injection for the Treatment of Stress Urinary Incontinence in Females: A Randomized Placebo-Controlled Trial.” Urology, December 2024, S009042952401118X. https://doi.org/10.1016/j.urology.2024.11.066.
- Long, Cheng-Yu. “A Pilot Study: Effectiveness of Local Injection of Autologous Platelet-Rich Plasma in Treating Women with Stress Urinary Incontinence.” Scientific Reports, 2021, 9.
- Matz, Ethan L, Amy M Pearlman, and Ryan P Terlecki. “Safety and Feasibility of Platelet Rich Fibrin Matrix Injections for Treatment of Common Urologic Conditions.” Investigative and Clinical Urology 59, no. 1 (2018): 61–65. https://doi.org/10.4111/icu.2018.59.1.61.
- Moccia, Felice, Paola Pentangelo, Alessandra Ceccaroni, Antonio Raffone, Luigi Losco, and Carmine Alfano. “Injection Treatments for Vulvovaginal Atrophy of Menopause: A Systematic Review.” Aesthetic Plastic Surgery, ahead of print, August 14, 2023. https://doi.org/10.1007/s00266-023-03550-5.
- Prodromidou, Anastasia, Themos Grigoriadis, and Stavros Athanasiou. “Platelet Rich Plasma for the Management of Urogynecological Disorders: The Current Evidence.” Current Opinion in Obstetrics & Gynecology Publish Ahead of Print (August 2022). https://doi.org/10.1097/GCO.0000000000000820.
- Runels, Charles. “A Pilot Study of the Effect of Localized Injections of Autologous Platelet Rich Plasma (PRP) for the Treatment of Female Sexual Dysfunction.” Journal of Women’s Health Care 03, no. 04 (2014). https://doi.org/10.4172/2167-0420.1000169.
- Sanoulis, Vasileios, Nikolaos Nikolettos, and Nikolaos Vlahos. The Use of Platelet-Rich Plasma in the Gynaecological Clinical Setting. A Review. 18, no. 3 (2019): 11.
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The Gap
When it comes to treating sexual dysfunction, Dr. Charles Runels sees a widening gap between the medical remedies for men and women — and medical education is partly to blame. https://t.co/FGLM0ebdYu
— Medscape (@Medscape) September 25, 2024
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O-Shot® (Orchid Shot®) Could Decrease Chances of Cancer
The following research showed that our O-Shot® techniques using PRP could decrease the chances of the development of squamous cell carcinoma in women suffering from lichen sclerosus.
Over a period of about nine years, none of the 319 women followed developed squamous cell carcinoma after treatment with PRP.
=>Here’s the research to read as a pdf<–
=>Where to find a physician offering the procedure in your area<–
-> Where your physician can find more information (click) about the procedure (the web page you are reading now is only for education; your physician (in consultation with you) can best determine your treatment.
-> Here’s where you can calculate your Female Sexual Function Index (free online test)<–
Here’s more research about PRP and it’s benefit for lichen sclerosus…
- Casabona, Francesco, Ilaria Gambelli, Federica Casabona, Pierluigi Santi, Gregorio Santori, and Ilaria Baldelli. “Autologous Platelet-Rich Plasma (PRP) in Chronic Penile Lichen Sclerosus: The Impact on Tissue Repair and Patient Quality of Life.” International Urology and Nephrology 49, no. 4 (April 2017): 573–80. https://doi.org/10.1007/s11255-017-1523-0.
- Casabona, Francesco, Virginia Priano, Valerio Vallerino, Angela Cogliandro, and Giorgio Lavagnino. “New Surgical Approach to Lichen Sclerosus of the Vulva: The Role of Adipose-Derived Mesenchymal Cells and Platelet-Rich Plasma in Tissue Regeneration.” Plastic and Reconstructive Surgery 126, no. 4 (2010): 210e–11.
- Cattaneo, A., P. Carli, A. De Marco, L. Sonni, G. Bracco, A. De Magnis, and G. L. Taddei. “Testosterone Maintenance Therapy. Effects on Vulvar Lichen Sclerosus Treated with Clobetasol Propionate.” The Journal of Reproductive Medicine 41, no. 2 (February 1996): 99–102.
- Chin, Simone, James Scurry, Jennifer Bradford, Geoffrey Lee, and Gayle Fischer. “Association of Topical Corticosteroids With Reduced Vulvar Squamous Cell Carcinoma Recurrence in Patients With Vulvar Lichen Sclerosus.” JAMA Dermatology 156, no. 7 (July 1, 2020): 813–14. https://doi.org/10.1001/jamadermatol.2020.1074.
- Franic, D., Z. Iternička, and M. Franić-Ivanišević. “Platelet-Rich Plasma (PRP) for the Treatment of Vulvar Lichen Sclerosus in a Premenopausal Woman: A Case Report.” Case Reports in Women’s Health 18 (April 2018): e00062. https://doi.org/10.1016/j.crwh.2018.e00062.
- Garrido-Colmenero, Cristina, Carmen María Martínez-Peinado, Manuel Galán-Gutiérrez, Virginia Barranco-Millán, and Ricardo Ruiz-Villaverde. “Successful Response of Vulvar Lichen Sclerosus with NB-UVB.” Dermatologic Therapy 34, no. 2 (2021): e14801. https://doi.org/10.1111/dth.14801.
- Goldstein, Andrew T., Michelle King, Charles Runels, Meghan Gloth, and Richard Pfau. “Intradermal Injection of Autologous Platelet-Rich Plasma for the Treatment of Vulvar Lichen Sclerosus.” Journal of the American Academy of Dermatology 76, no. 1 (January 2017): 158–60. https://doi.org/10.1016/j.jaad.2016.07.037.
- Goldstein, Andrew T., Leia Mitchell, Vaishnavi Govind, and Debra Heller. “A Randomized Double-Blind Placebo Controlled Trial of Autologous Platelet Rich Plasma Intradermal Injections for the Treatment of Vulvar Lichen Sclerosus.” Journal of the American Academy of Dermatology, January 2019. https://doi.org/10.1016/j.jaad.2018.12.060.
- Goodchild, Sophie. “How Kim Kardashian’s Vampire Facial Could Provide Relief to 1m Women.” Mail Online, November 5, 2022. https://www.dailymail.co.uk/health/article-11393613/How-Kim-
- Kardashians-vampire-facial-provide-relief-1m-British-women.html.
- Gulin, Sandra Jerkovic, Filippa Lundin, and Oliver Seifert. “Comorbidity in Patients with Lichen Sclerosus: A Retrospective Cohort Study.” European Journal of Medical Research 28, no. 1 (September 11, 2023): 338. https://doi.org/10.1186/s40001-023-01335-9.
- Gunthert, A.R., K. Duclos, B.G. Jahns, and et al. “Clinical Scoring System for Vulvar Lichen Sclerosus.” J Sex Med 9 (2012): 2342–50.
- Gutierrez-Ontalvilla, P., F. Giner, L. Vidal, and M. Iborra. “The Effect of Lipofilling and Platelet-Rich Plasma on Patients with Moderate-Severe Vulvar Lichen Sclerosus Who Were Non-Responders to Topical Clobetasol Propionate: A Randomized Pilot Study.” Aesthetic Plastic Surgery 46, no. 5 (October 2022): 2469–79. https://doi.org/10.1007/s00266-021-02718-1.
- Krogh, G von, K Dahlman-Ghozlan, and S Syrjänen. “Potential Human Papillomavirus Reactivation Following Topical Corticosteroid Therapy of Genital Lichen Sclerosus and Erosive Lichen Planus.” Journal of the European Academy of Dermatology and Venereology : JEADV 16, no. 2 (March 2002): 130–33. http://www.ncbi.nlm.nih.gov/pubmed/12046814.
- Lee, A., J. Bradford, and G. Fischer. “Long-Term Management of Adult Vulvar Lichen Sclerosus: A Prospective Cohort Study of 507 Women.” JAMA Dermatol 151 (2015): 1061–67.
- Marnach, Mary L., and Rochelle R. Torgerson. “Therapeutic Interventions for Challenging Cases of Vulvar Lichen Sclerosus and Lichen Planus.” Obstetrics & Gynecology 138, no. 3 (September 2021): 374–78. https://doi.org/10.1097/AOG.0000000000004498.
- Mitchell, Leia, Andrew T. Goldstein, Debra Heller, Theodora Mautz, Chelsea Thorne, So Yeon Joyce Kong, Maria E. Sophocles, Hillary Tolson, and Jill M. Krapf. “Fractionated Carbon Dioxide Laser for the Treatment of Vulvar Lichen Sclerosus: A Randomized Controlled Trial.” Obstetrics & Gynecology 137, no. 6 (June 2021): 979–87. https://doi.org/10.1097/AOG.0000000000004409.
- “New Surgical Approach to Lichen Sclerosus of the Vulva: The Role of Adipose-Derived Mesenchymal Cells and Platelet-Rich Plasma in Tissue Regeneration. Casabona F1, Priano V.” Plast Reconstr Surg., n.d.
- Origoni, M., D. Ferrari, M. Rossi, F. Gandini, M. Sideri, and A. Ferrari. “Topical Oxatomide: An Alternative Approach for the Treatment of Vulvar Lichen Sclerosus.” International Journal of Gynecology & Obstetrics 55, no. 3 (December 1996): 259–64. https://doi.org/10.1016/S0020-7292(96)02768-3.
- Pensato, Rosita, and Simone La Padula. “The Effect of Lipofilling and Platelet-Rich Plasma on Patients with Moderate–Severe Vulvar Lichen Sclerosus Who Were Non-Responders to Topical Clobetasol Propionate: A Randomized Pilot Study.” Aesthetic Plastic Surgery, May 31, 2022. https://doi.org/10.1007/s00266-022-02947-y.
- Posey, Kathleen, and Charles Runels. “In-Office Surgery and Use of Platelet Rich Plasma for Treatment of Vulvar Lichen Sclerosus to Alleviate Painful Sexual Intercourse.” Journal of Lower Genital Tract Disease 19, no. 3 (July 2015): S1–25. https://doi.org/10.1097/lgt.0000000000000121.
- Qing, Chun, Xiaoyong Mao, Gaoqing Liu, Yibin Deng, and Xiaokun Yang. “The Efficacy and Safety of 5-Aminolevulinic Acid Photodynamic Therapy for Lichen Sclerosus: A Meta Analysis.” Indian Journal of Dermatology 68, no. 1 (2023): 1–7. https://doi.org/10.4103/ijd.ijd_925_21.
- Tedesco, M., G. Pranteda, G. Chichierchia, and et al. “The Use of PRP (Platelet-Rich Plasma) in Patients Affected by Genital Lichen Sclerosus: Clinical Analysis and Results.” J Eur Acad Dermatol Venereol 33 (2019): e58–59.
- Vittrup, G., L. Mørup, T. Heilesen, D. Jensen, S. Westmark, and D. Melgaard. “The Quality of Life and Sexuality in Women with Lichen Sclerosus – A Cross Sectional Study.” Clinical and Experimental Dermatology n/a, no. n/a. Accessed August 31, 2021. https://doi.org/10.1111/ced.14893.
