Year: 2025

  • The Science Behind the “Revenge Vagina”

    What is the “Revenge Vagina”?

    When a woman is hurt by separation and seeks revenge on her ex-lover or husband, not by directly harming the ex-lover, but instead by making herself as healthy, peaceful, and desirable as possible–including sexual health.

    The phrase, “revenge vagina,” was made popular when Kim Kardashian’s character, Allura Grant, talks about having PRP injected into and around her vagina, achieving the “most smooth and plump…perfection” as part of her revenge strategy; hence, the “revenge vagina.”

    The procedure can also work another way: by improving sex before women are separated from their spouses, it has helped bring thousands of couples closer together to prevent divorce–the “enchanting vagina.”

    The first physician to describe such injections (using PRP and other blood-derived growth factors to improve sexual function) to the US Patent & Trademark Office in 2012 was Charles Runels. He first published research about his specific technique in 2014. Since then, over 3,000 research papers have documented the effectiveness of this therapy.

    The O-Shot® procedure is the only documented, standardized protocol, now in use for over a decade by thousands of doctors in more than 50 countries.

    He and his wife describe the latest science behind the procedure in their recent lecture, shown below…

    Licensed providers of his technique, the O-Shot® procedure can be found here<–

    Physicians and physician extenders can apply for training here<–

    References

    More references here<–

    Agar, N. S., and T. Stephens. “Reduced Glutathione–a Comparative Study of Erythrocytes from Various Species of Marsupials in Australia.” Comparative Biochemistry and Physiology. A, Comparative Physiology 52, no. 4 (1975): 605–6. https://doi.org/10.1016/s0300-9629(75)80008-9.

    Handy, Ariel B., Amelia M. Stanton, and Cindy M. Meston. “Understanding Women’s Subjective Sexual Arousal Within the Laboratory: Definition, Measurement, and Manipulation.” Sexual Medicine Reviews 6, no. 2 (2018): 201–16. https://doi.org/10.1016/j.sxmr.2017.11.001.

    Hersant, Barbara, Mounia SidAhmed-Mezi, Yazid Belkacemi, et al. “Efficacy of Injecting Platelet Concentrate Combined with Hyaluronic Acid for the Treatment of Vulvovaginal Atrophy in Postmenopausal Women with History of Breast Cancer.” Menopause 25, no. 10 (2018): 1. https://doi.org/10.1097/GME.0000000000001122.

    Jb, Neto. O-Shot: Platelets Rich Plasma in Intimate Female Treatment. 2017, 4.

    Jhang, Jia-Fong, Shu-Yu Wu, Teng-Yi Lin, and Hann-Chorng Kuo. “Repeated Intravesical Injections of Platelet-Rich Plasma Are Effective in the Treatment of Interstitial Cystitis: A Case Control Pilot Study.” LUTS: Lower Urinary Tract Symptoms 11, no. 2 (2019): O42–47. https://doi.org/10.1111/luts.12212.

    Jhang, Jia-Fong, Shu-Yu Wu, Teng-Yi Lin, and Hann-Chorng Kuo. “Repeated Intravesical Injections of Platelet-Rich Plasma Are Effective in the Treatment of Interstitial Cystitis: A Case Control Pilot Study.” LUTS: Lower Urinary Tract Symptoms 11, no. 2 (2019): O42–47. https://doi.org/10.1111/luts.12212.

    Liu, Zhaoxue, Yuan Tang, Jiaojiao Liu, et al. “Platelet-Rich Plasma Promotes Restoration of The Anterior Vaginal Wall for The Treatment of Pelvic Floor Dysfunction in Rats.” Journal of Minimally Invasive Gynecology, October 2022, S1553465022009463. https://doi.org/10.1016/j.jmig.2022.10.004.

    Long, Cheng-Yu. “A Pilot Study: Effectiveness of Local Injection of Autologous Platelet-Rich Plasma in Treating Women with Stress Urinary Incontinence.” Scientific Reports, 2021, 9.

    Matz, Ethan L, Amy M Pearlman, and Ryan P Terlecki. “Safety and Feasibility of Platelet Rich Fibrin Matrix Injections for Treatment of Common Urologic Conditions.” Investigative and Clinical Urology 59, no. 1 (2018): 61–65. https://doi.org/10.4111/icu.2018.59.1.61.

    Merhi, Zaher, Serin Seckin, and Marco Mouanness. REPRODUCTIVE ENDOCRINOLOGY: CASE STUDY Intraovarian PRP Injection Improved Hot Flashes in a Woman With Very Low Ovarian Reserve. n.d. https://doi.org/10.1007/s43032-021-00655-7.

    Moccia, Felice, Paola Pentangelo, Alessandra Ceccaroni, Antonio Raffone, Luigi Losco, and Carmine Alfano. “Injection Treatments for Vulvovaginal Atrophy of Menopause: A Systematic Review.” Aesthetic Plastic Surgery, ahead of print, August 14, 2023. https://doi.org/10.1007/s00266-023-03550-5.

    Nikolopoulos, Kostis I., Vasilios Pergialiotis, Despina Perrea, and Stergios K. Doumouchtsis. “Restoration of the Pubourethral Ligament with Platelet Rich Plasma for the Treatment of Stress Urinary Incontinence.” Medical Hypotheses 90 (May 2016): 29–31. https://doi.org/10.1016/j.mehy.2016.02.019.

    O-Shot® | Orgasm Shot® | Research | O Shot. April 11, 2017. https://oshot.info/research/.

    Prodromidou, Anastasia, Themos Grigoriadis, and Stavros Athanasiou. “Platelet Rich Plasma for the Management of Urogynecological Disorders: The Current Evidence.” Current Opinion in Obstetrics & Gynecology Publish Ahead of Print (August 2022). https://doi.org/10.1097/GCO.0000000000000820.

    Prodromidou, Anastasia, Dimitrios Zacharakis, and Stavros Athanasiou. The Emerging Role on the Use of Platelet-Rich Plasma Products in the Management of Urogynaecological Disorders. 2021. https://doi.org/10.1177/15533506211014848.

    Prodromidou, Anastasia, Dimitrios Zacharakis, Stavros Athanasiou, et al. “The Emerging Role on the Use of Platelet-Rich Plasma Products in the Management of Urogynaecological Disorders.” Surgical Innovation, SAGE Publications Inc, April 28, 2021, 15533506211014848. https://doi.org/10.1177/15533506211014848.

    Runels, Charles. “A Pilot Study of the Effect of Localized Injections of Autologous Platelet Rich Plasma (PRP) for the Treatment of Female Sexual Dysfunction.” Journal of Women’s Health Care 03, no. 04 (2014). https://doi.org/10.4172/2167-0420.1000169.

    Runels, Charles, Hugh Melnick, Ernest Debourbon, and Lisbeth Roy. “A Pilot Study of the Effect of Localized Injections of Autologous Platelet Rich Plasma ( PRP ) for the Treatment of Female Sexual Dysfunction.” Women’s Health Care 3, no. 4 (2014): 3–6. https://doi.org/10.4172/2167-0420.100016.

    Sanoulis, Vasileios, Nikolaos Nikolettos, and Nikolaos Vlahos. The Use of Platelet-Rich Plasma in the Gynaecological Clinical Setting. A Review. 18, no. 3 (2019): 11.

    Sanoulis, Vasileios, Nikolaos Nikolettos, and Nikolaos Vlahos. “The Use of Platelet-Rich Plasma in the Gynaecological Clinical Setting. A Review.” Hellenic Journal of Obstetrics and Gynecology 18, no. 3 (2019): 55–65. https://doi.org/10.33574/hjog.1766.

    Share, J. B. “Review of Drug Treatment for Down’s Syndrome Persons.” American Journal of Mental Deficiency 80, no. 4 (1976): 388–93.

    Sharp, Gemma, Pascale Maynard, Christine A Hamori, Jayson Oates, David B Sarwer, and Jayashri Kulkarni. “Measuring Quality of Life in Female Genital Cosmetic Procedure Patients: A Systematic Review of Patient-Reported Outcome Measures.” Aesthetic Surgery Journal 40, no. 3 (2020): 311–18. https://doi.org/10.1093/asj/sjz325.

    Sills, Eric Scott, Xiang Li, Natalie S Rickers, Samuel H Wood, and Gianpiero D Palermo. “Metabolic and Neurobehavioral Response Following Intraovarian Administration of Autologous Activated Platelet Rich Plasma: First Qualitative Data.” Neuro Endocrinology Letters 39, no. 6 (2019): 427–33. http://www.ncbi.nlm.nih.gov/pubmed/30796792.

    Willison, Nadia, Fariba Behnia-Willison, Pouria Aryan, et al. “Application of Platelet-Rich Plasma in Gynaecologic Disorders: A Scoping Review.” Journal of Clinical Medicine 14, no. 16 (2025): 5832. https://doi.org/10.3390/jcm14165832.

    Zheng, Zhifang. Materials Selection for the Injection into Vaginal Wall for Treatment of Vaginal Atrophy. 2021, 11.

  • Over 9 Years of O-Shot® Data

    Find the nearest O-Shot® provider<–

    O-Shot® research<–

    Cellular Medicine Association

    Apply for Training for the O-Shot® Procedure

  • Lynkuet® Combined Second Therapy for a Powerful Synergy to Help Women Suffering from Breast Cancer

     

    A hormone‑free approach to relieve vaginal dryness and discomfort — and how O‑Shot® and Lynkuet™ can work together.

  • You are not broken, You are unbalanced

    Book cover titled 'YOU'RE NOT BROKEN YOU'RE UNBALANCED' by Travis Woodley, featuring a smiling man holding a coffee cup, with a background of health-related themes.

    Travis Woodley is a brilliant healer and concerned scholar. Pay attention to this book!

    Charles Runels, MD

  • Stress Urinary Incontinence in Teenage Women

    Read the research referenced in the video<- Find the nearest O-Shot® Provider<-

    Some of the Research Supporting the Effectiveness of the O-Shot® Procedure for Treating Stress Urinary Incontinence

    • Ashton, Leah, Hannah Nakatsuka, Colin M. Johnson, et al. “A Single Injection of Platelet-Rich Plasma Injection for the Treatment of Stress Urinary Incontinence in Females: A Randomized Placebo-Controlled Trial.” Urology 193 (November 2024): 63–68. https://doi.org/10.1016/j.urology.2024.06.047.
    • Boztepe, Ozlem, and Hannah Warren. “Letter to Editor – A Single Injection of Platelet-Rich Plasma Injection for the Treatment of Stress Urinary Incontinence in Females: A Randomized Placebo-Controlled Trial.” Urology, December 2024, S009042952401118X. https://doi.org/10.1016/j.urology.2024.11.066.
    • Long, Cheng-Yu. “A Pilot Study: Effectiveness of Local Injection of Autologous Platelet-Rich Plasma in Treating Women with Stress Urinary Incontinence.” Scientific Reports, 2021, 9.
    • Matz, Ethan L, Amy M Pearlman, and Ryan P Terlecki. “Safety and Feasibility of Platelet Rich Fibrin Matrix Injections for Treatment of Common Urologic Conditions.” Investigative and Clinical Urology 59, no. 1 (2018): 61–65. https://doi.org/10.4111/icu.2018.59.1.61.
    • Moccia, Felice, Paola Pentangelo, Alessandra Ceccaroni, Antonio Raffone, Luigi Losco, and Carmine Alfano. “Injection Treatments for Vulvovaginal Atrophy of Menopause: A Systematic Review.” Aesthetic Plastic Surgery, ahead of print, August 14, 2023. https://doi.org/10.1007/s00266-023-03550-5.
    • Prodromidou, Anastasia, Themos Grigoriadis, and Stavros Athanasiou. “Platelet Rich Plasma for the Management of Urogynecological Disorders: The Current Evidence.” Current Opinion in Obstetrics & Gynecology Publish Ahead of Print (August 2022). https://doi.org/10.1097/GCO.0000000000000820.
    • Runels, Charles. “A Pilot Study of the Effect of Localized Injections of Autologous Platelet Rich Plasma (PRP) for the Treatment of Female Sexual Dysfunction.” Journal of Women’s Health Care 03, no. 04 (2014). https://doi.org/10.4172/2167-0420.1000169.
    • Sanoulis, Vasileios, Nikolaos Nikolettos, and Nikolaos Vlahos. The Use of Platelet-Rich Plasma in the Gynaecological Clinical Setting. A Review. 18, no. 3 (2019): 11.

  • Female Orgasm System

    More about the International Society of Cosmetogynecology<–

    More about the Female Orgasm System<–

    Buy the Female Orgasm System poster<–

    Medscape article about the female orgasm system<–

    Physicians apply for training to offer the O-Shot® procedure<–

    Find the nearest O-Shot® provider<–

  • Female Orgasm System Poster


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  • The Gap

  • O-Shot® (Orchid Shot®) Could Decrease Chances of Cancer

    O-Shot® (Orchid Shot®) Could Decrease Chances of Cancer

    The following research showed that our O-Shot® techniques using PRP could decrease the chances of the development of squamous cell carcinoma in women suffering from lichen sclerosus.

    Over a period of about nine years, none of the 319 women followed developed squamous cell carcinoma after treatment with PRP.

    =>Here’s the research to read as a pdf<–

    =>Where to find a physician offering the procedure in your area<–

    -> Where your physician can find more information (click) about the procedure (the web page you are reading now is only for education; your physician (in consultation with you) can best determine your treatment.

    -> Here’s where you can calculate your Female Sexual Function Index (free online test)<–

    Here’s more research about PRP and it’s benefit for lichen sclerosus…

    • Casabona, Francesco, Ilaria Gambelli, Federica Casabona, Pierluigi Santi, Gregorio Santori, and Ilaria Baldelli. “Autologous Platelet-Rich Plasma (PRP) in Chronic Penile Lichen Sclerosus: The Impact on Tissue Repair and Patient Quality of Life.” International Urology and Nephrology 49, no. 4 (April 2017): 573–80. https://doi.org/10.1007/s11255-017-1523-0.
    • Casabona, Francesco, Virginia Priano, Valerio Vallerino, Angela Cogliandro, and Giorgio Lavagnino. “New Surgical Approach to Lichen Sclerosus of the Vulva: The Role of Adipose-Derived Mesenchymal Cells and Platelet-Rich Plasma in Tissue Regeneration.” Plastic and Reconstructive Surgery 126, no. 4 (2010): 210e–11.
    • Cattaneo, A., P. Carli, A. De Marco, L. Sonni, G. Bracco, A. De Magnis, and G. L. Taddei. “Testosterone Maintenance Therapy. Effects on Vulvar Lichen Sclerosus Treated with Clobetasol Propionate.” The Journal of Reproductive Medicine 41, no. 2 (February 1996): 99–102.
    • Chin, Simone, James Scurry, Jennifer Bradford, Geoffrey Lee, and Gayle Fischer. “Association of Topical Corticosteroids With Reduced Vulvar Squamous Cell Carcinoma Recurrence in Patients With Vulvar Lichen Sclerosus.” JAMA Dermatology 156, no. 7 (July 1, 2020): 813–14. https://doi.org/10.1001/jamadermatol.2020.1074.
    • Franic, D., Z. Iternička, and M. Franić-Ivanišević. “Platelet-Rich Plasma (PRP) for the Treatment of Vulvar Lichen Sclerosus in a Premenopausal Woman: A Case Report.” Case Reports in Women’s Health 18 (April 2018): e00062. https://doi.org/10.1016/j.crwh.2018.e00062.
    • Garrido-Colmenero, Cristina, Carmen María Martínez-Peinado, Manuel Galán-Gutiérrez, Virginia Barranco-Millán, and Ricardo Ruiz-Villaverde. “Successful Response of Vulvar Lichen Sclerosus with NB-UVB.” Dermatologic Therapy 34, no. 2 (2021): e14801. https://doi.org/10.1111/dth.14801.
    • Goldstein, Andrew T., Michelle King, Charles Runels, Meghan Gloth, and Richard Pfau. “Intradermal Injection of Autologous Platelet-Rich Plasma for the Treatment of Vulvar Lichen Sclerosus.” Journal of the American Academy of Dermatology 76, no. 1 (January 2017): 158–60. https://doi.org/10.1016/j.jaad.2016.07.037.
    • Goldstein, Andrew T., Leia Mitchell, Vaishnavi Govind, and Debra Heller. “A Randomized Double-Blind Placebo Controlled Trial of Autologous Platelet Rich Plasma Intradermal Injections for the Treatment of Vulvar Lichen Sclerosus.” Journal of the American Academy of Dermatology, January 2019. https://doi.org/10.1016/j.jaad.2018.12.060.
    • Goodchild, Sophie. “How Kim Kardashian’s Vampire Facial Could Provide Relief to 1m Women.” Mail Online, November 5, 2022. https://www.dailymail.co.uk/health/article-11393613/How-Kim-
    • Kardashians-vampire-facial-provide-relief-1m-British-women.html.
    • Gulin, Sandra Jerkovic, Filippa Lundin, and Oliver Seifert. “Comorbidity in Patients with Lichen Sclerosus: A Retrospective Cohort Study.” European Journal of Medical Research 28, no. 1 (September 11, 2023): 338. https://doi.org/10.1186/s40001-023-01335-9.
    • Gunthert, A.R., K. Duclos, B.G. Jahns, and et al. “Clinical Scoring System for Vulvar Lichen Sclerosus.” J Sex Med 9 (2012): 2342–50.
    • Gutierrez-Ontalvilla, P., F. Giner, L. Vidal, and M. Iborra. “The Effect of Lipofilling and Platelet-Rich Plasma on Patients with Moderate-Severe Vulvar Lichen Sclerosus Who Were Non-Responders to Topical Clobetasol Propionate: A Randomized Pilot Study.” Aesthetic Plastic Surgery 46, no. 5 (October 2022): 2469–79. https://doi.org/10.1007/s00266-021-02718-1.
    • Krogh, G von, K Dahlman-Ghozlan, and S Syrjänen. “Potential Human Papillomavirus Reactivation Following Topical Corticosteroid Therapy of Genital Lichen Sclerosus and Erosive Lichen Planus.” Journal of the European Academy of Dermatology and Venereology : JEADV 16, no. 2 (March 2002): 130–33. http://www.ncbi.nlm.nih.gov/pubmed/12046814.
    • Lee, A., J. Bradford, and G. Fischer. “Long-Term Management of Adult Vulvar Lichen Sclerosus: A Prospective Cohort Study of 507 Women.” JAMA Dermatol 151 (2015): 1061–67.
    • Marnach, Mary L., and Rochelle R. Torgerson. “Therapeutic Interventions for Challenging Cases of Vulvar Lichen Sclerosus and Lichen Planus.” Obstetrics & Gynecology 138, no. 3 (September 2021): 374–78. https://doi.org/10.1097/AOG.0000000000004498.
    • Mitchell, Leia, Andrew T. Goldstein, Debra Heller, Theodora Mautz, Chelsea Thorne, So Yeon Joyce Kong, Maria E. Sophocles, Hillary Tolson, and Jill M. Krapf. “Fractionated Carbon Dioxide Laser for the Treatment of Vulvar Lichen Sclerosus: A Randomized Controlled Trial.” Obstetrics & Gynecology 137, no. 6 (June 2021): 979–87. https://doi.org/10.1097/AOG.0000000000004409.
    • “New Surgical Approach to Lichen Sclerosus of the Vulva: The Role of Adipose-Derived Mesenchymal Cells and Platelet-Rich Plasma in Tissue Regeneration. Casabona F1, Priano V.” Plast Reconstr Surg., n.d.
    • Origoni, M., D. Ferrari, M. Rossi, F. Gandini, M. Sideri, and A. Ferrari. “Topical Oxatomide: An Alternative Approach for the Treatment of Vulvar Lichen Sclerosus.” International Journal of Gynecology & Obstetrics 55, no. 3 (December 1996): 259–64. https://doi.org/10.1016/S0020-7292(96)02768-3.
    • Pensato, Rosita, and Simone La Padula. “The Effect of Lipofilling and Platelet-Rich Plasma on Patients with Moderate–Severe Vulvar Lichen Sclerosus Who Were Non-Responders to Topical Clobetasol Propionate: A Randomized Pilot Study.” Aesthetic Plastic Surgery, May 31, 2022. https://doi.org/10.1007/s00266-022-02947-y.
    • Posey, Kathleen, and Charles Runels. “In-Office Surgery and Use of Platelet Rich Plasma for Treatment of Vulvar Lichen Sclerosus to Alleviate Painful Sexual Intercourse.” Journal of Lower Genital Tract Disease 19, no. 3 (July 2015): S1–25. https://doi.org/10.1097/lgt.0000000000000121.
    • Qing, Chun, Xiaoyong Mao, Gaoqing Liu, Yibin Deng, and Xiaokun Yang. “The Efficacy and Safety of 5-Aminolevulinic Acid Photodynamic Therapy for Lichen Sclerosus: A Meta Analysis.” Indian Journal of Dermatology 68, no. 1 (2023): 1–7. https://doi.org/10.4103/ijd.ijd_925_21.
    • Tedesco, M., G. Pranteda, G. Chichierchia, and et al. “The Use of PRP (Platelet-Rich Plasma) in Patients Affected by Genital Lichen Sclerosus: Clinical Analysis and Results.” J Eur Acad Dermatol Venereol 33 (2019): e58–59.
    • Vittrup, G., L. Mørup, T. Heilesen, D. Jensen, S. Westmark, and D. Melgaard. “The Quality of Life and Sexuality in Women with Lichen Sclerosus – A Cross Sectional Study.” Clinical and Experimental Dermatology n/a, no. n/a. Accessed August 31, 2021. https://doi.org/10.1111/ced.14893.